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1. Overexpression of microRNA gga-miR-21 in chicken fibroblasts suppresses replication of infectious bursal disease virus through inhibiting VP1 translation.

Author

Wang, Yong-shan, Ouyang, Wei, Pan, Qun-xing, Wang, Xiao-li, Xia, Xing-xia, Bi, Zhen-wei, Wang, Yong-qiang, and Wang, Xiao-mei

Subjects
*MICRORNA, *GENE expression, *FIBROBLASTS, *INFECTIOUS bursal disease virus, *GENETIC translation, *VIRAL replication
Abstract

Highlights: [•] A chicken fibroblast cell line stably overexpressing gga-miRNA-21 was established. [•] IBDV replication is suppressed in chicken fibroblasts overexpressing gga-miR-21. [•] IBDV genome segment B (VP1) nt1713–1734 is a gga-miR-21 target sequence. [•] IBDV VP1 protein but not mRNA is suppressed in gga-miR-21 overexpressing cells. [Copyright &y& Elsevier]

Published
2013
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