Search

Your search keyword '"Toti, M."' showing total 5 results
Start Over Author "Toti, M." Journal antiviral therapy
5 results on '"Toti, M."'

1. Evolution of HVR-1 Quasispecies after 1-Year Treatment in HIV/HCV-Coinfected Patients According to the Pattern of Response to Highly Active Antiretroviral Therapy

Author

Ancarani, F, Angeli, E, Antinori, A, Antonucci, G, Bonasso, M, Bruno, R, Capobianchi, MR, Cargnel, A, Cozzi-Lepri, A, Monforte, A d'Arminio, Cingolani, A, Galli, M, Orofino, GC, Girardi, E, Marino, N, Bongiovanni, M, Morsica, G, Narciso, P, Pastecchia, C, Pizzaferri, P, Puoti, M, Santantonio, T, Verucchi, G, Montroni, M, Scalise, G, Braschi, MC, Maracci, M, Tirelli, U, Cinelli, R, Pastore, G, Ladisa, N, Minafra, G, Suter, F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cadeo, GP, Torti, C, Minardi, C, Bertelli, D, Rizzardini, G, Migliorino, G, Manconi, PE, Piano, P, Ferraro, T, Scerbo, A, Pizzigallo, E, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Galloni, D, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Caputo, S Lo, Angarano, G, Grisorio, B, Saracino, A, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Toti, M, Chigiotti, S, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Fibbia, G, Moroni, M, Lazzarin, A, Cargnel, A, Vigevani, GM, Caggese, L, Monforte, A d'Arminio, Repetto, D, Novati, R, Galli, A, Merli, S, Pastecchia, C, Moioli, MC, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Izzo, CM, Piazza, M, De Marco, M, Viglietti, R, Manzillo, E, Graf, M, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Baldelli, F, Tinca, M, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, La Gala, A, Ballardini, G, Briganti, E, Magnani, G, Ursitti, MA, Arlotti, M, Ortolani, P, Cauda, R, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Di Giambenedetti, S, Zaccarelli, M, Acinapura, R, De Longis, P, Ciardi, M, D'Offizi, G, Trotta, MP, Noto, P, Lichtner, M, Capobianchi, MR, Girardi, E, Pezzotti, P, Rezza, G, Mura, MS, Mannazzu, M, Resta, F, Loso, K, Caramello, P, Sinicco, A, Soranzo, ML, Orofino, G, Sciandra, M, Bonasso, M, Grossi, PA, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, De Lalla, F, Tositti, G, Lepri, A Cozzi, Solmone, Mariacarmela, Girardi, Enrico, Lalle, Eleonora, Abbate, Isabella, Monforte, Antonella D'Arminio, Cozzi-Lepri, Alessandro, Alessandrini, Anna, Piscopo, Rita, Ebo, Francesca, Cosco, Lucio, Antonucci, Giorgio, Ippolito, Giuseppe, and Capobianchi, Maria R

Abstract

Hepatitis C virus (HCV) variability is mainly attributed to the ability of the virus to respond to host immune pressure, acting as a driving force for the evolution of quasispecies. This study was aimed at studying the changes in HVR-1 heterogeneity and the evolution of HCV quasispecies in HIV/HCV-coinfected patients according to the pattern of response to highly active antiretroviral therapy (HAART).Sixteen HIV/HCV-coinfected patients harbouring HCV genotype 1 and who had been on HAART for at least 1 year, 8 showing increasing CD4+T-cell counts (immunological responders) and 8 showing a stable or decreasing CD4+T-cell counts (immunological non-responders), were selected from a prospective cohort study.After 1 year of HAART, 11 patients showed HIV viral load <2.6 log10cp/ml (virological responders), and 5 showed HIV viral load above this value (virological non-responders). Plasma samples, collected before starting therapy and after 1 year of HAART, underwent clonal sequence analysis for HVR-1 region of HCV. Non-synonymous/synonymous substitutions ratio (Ka/Ks), aminoacidic complexity (normalized Shannon entropy) and diversity (p-distance), were considered as parameters of quasispecies heterogeneity. After 1 year of HAART, heterogeneity of HVR-1 quasispecies significantly decreased in virological non-responders, whereas the heterogeneity tended to increase in virological responders. The differences in the evolution were less stringent, when considering immunological response. On the other hand, profound qualitative modifications of HVR-1 quasispecies were observed only in patients with both immunological and virological HAART response.On the whole, these findings suggest that, in patients undergoing HAART, the extent of HCV variability and the evolution of HVR-1 quasispecies is influenced by the pattern of response to antiretroviral therapy.

Published
2006
Full Text
View/download PDF

2. Response to Haart and Gb Virus Type C Coinfection in a Cohort of Antiretroviral-Naive HIV-Infected Individuals

Author

Antonucci, Giorgio, Girardi, Enrico, Cozzi-Lepri, Alessandro, Capobianchi, Maria Rosaria, Morsica, Giulia, Pizzaferri, Paolo, Ladisa, Nicoletta, Sighinolfi, Laura, Chiodera, Alessandro, Solmone, Mariacarmela, Lalle, Eleonora, Ippolito, Giuseppe, Monforte, Antonella d'Arminio, Ancarani, F, Antinori, A, Antonucci, G, Bonasso, M, Bruno, R, Capobianchi, MR, Cargnel, A, Cozzi-Lepri, A, d'Arminio Monforte, A, Luca, A De, Galli, M, Gennero, L, Girardi, E, Lipani, F, Marino, N, Milazzo, L, Morsica, G, Narciso, P, Pizzaferri, P, Puoti, M, Santantonio, T, Verucchi, G, Montroni, M, Scalise, G, Braschi, MC, Prete, MS Del, Tirelli, U, Cinelli, R, Pastore, G, Ladisa, N, Suter, G Minafra. Bergamo: F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cadeo, GP, Torti, C, Minardi, C, Bertelli, D, Rizzardini, G, Migliorino, G, Manconi, PE, Piano, P, Ferraro, T, Scerbo, A, Pizzigallo, E, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Galloni, D, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Caputo, S Lo, Angarano, G, Grisorio, B, Saracino, A, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Toti, M, Chigiotti, S, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Fibbia, G, Moroni, M, Lazzarin, A, Cargnel, A, Vigevani, GM, Caggese, L, Monforte, A d'Arminio, Repetto, D, Novati, R, Galli, A, Merli, S, Pastecchia, C, Moioli, MC, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Izzo, CM, Piazza, M, Marco, M De, Viglietti, R, Manzillo, E, Graf, M, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Baldelli, F, Tinca, M, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, Stefano, C De, Gala, A La, Ballardini, G, Briganti, E, Magnani, G, Ursitti, MA, Arlotti, M, Ortolani, P, Cauda, R, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, Luca, A De, Giambenedetti, S Di, Zaccarelli, M, Acinapura, R, Longis, P De, Ciardi, M, D'Offizi, G, Trotta, MP, Noto, P, Lichtner, M, Capobianchi, MR, Girardi, E, Pezzotti, P, Rezza, G, Mura, MS, Mannazzu, M, Resta, F, Loso, K, Caramello, P, Sinicco, A, Soranzo, ML, Orofino, G, Sciandra, M, Bonasso, M, Grossi, PA, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, Lalla, F De, Tositti, G, and Lepri, A Cozzi

Abstract

The prognostic role of GB virus type C (GBV-C) viraemia in HIV-infected subjects treated with highly active antiretroviral therapy (HAART) is still undefined, The aim of this analysis is to assess the relationship between GBV-C infection and response to antiretroviral therapy among HIV-infected subjects initiating HAART when antiretroviral-naive.A prospective, observational study of 400 HIV-infected patients with measurements of GBV-C RNA, hepatitis C virus (HCV) antibodies and HCV RNA determined from plasma stored prior to HAART initiation, Time to virological (achieving HIV RNA =500 copies/ml) and immunological success (a CD4+ count increase of =200cells/µl), and the time to virological relapse (confirmed HIV RNA >500 copies/ml) were assessed by Kaplan-Meier methods and Cox proportional hazard regression model.Of the subjects, 117 (29.3%) were GBV-C positive and, overall, 351 (87.8%) patients achieved virological success, After controlling for a number of confounders including HCV RNA, GBV-C viraemic patients experienced a significantly lower risk of HIV rebound than those who were GBV-C negative [relative hazard (RH)=0.56, 95% CI: 0.34–0.93, P=0.03], Conversely, the probability of achieving initial virological success or CD4+ count response after HAART did not differ between GBV-C-negative and -positive subjects, These results suggest that GBV-C coinfection may play a role in determining the rate of HIV rebound possibly by competing with HIV replication after HIV load has been successfully suppressed by HAART.

Published
2005
Full Text
View/download PDF

3. The Management of Hepatitis B Virus/HIV-1 Co-Infected Patients Starting Their First Haart Regimen. Treating Two Infections for the Price of One Drug?

Author

Puoti, Massimo, Cozzi-Lepri, Alessandro, Ancarani, Fausto, Bruno, Raffaele, Ambu, Silvia, Ferraro, Teresa, Tundo, Paolo, Santantonio, Teresa, Toti, Mario, Bonasso, Marino, Monforte, Antonella d'Arminio, Ancarani, F, Antonucci, G, Bonasso, M, Bruno, R, Cozzi-Lepri, A, Monforte, A d'Arminio, Luca, A De, Galli, M, Gennero, L, Girardi, E, Lipani, F, Marino, N, Milazzo, L, Morsica, G, Narciso, P, Pizzaferri, P, Puoti, M, Santantonio, T, Verucchi, G, Montroni, M, Scalise, G, Zoli, A, Prete, MS Del, Tirelli, U, Di Gennaro, G, Pastore, G, Ladisa, N, Minafra, G, Suter, F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cadeo, GP, Castelli, F, Minardi, C, Vangi, D, Rizzardini, G, Migliorino, G, Manconi, PE, Piano, P, Ferraro, T, Scerbo, A, Pizzigallo, E, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Galloni, D, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Lo Caputo, S, Angarano, G, Grisorio, B, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Piersantelli, N, Alessandrini, A, Piscopo, R, Toti, M, Chigiotti, S, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Fibbia, G, Moroni, M, Lazzarin, A, Cargnel, A, Vigevani, GM, Caggese, L, d'Arminio Monforte, A, Repetto, D, Novati, R, Galli, A, Merli, S, Pastecchia, C, Moioli, MC, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Izzo, C, Piazza, M, De Marco, M, Montesarchio, V, Manzillo, E, Graf, M, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Balzelli, F, Loso, K, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, La Gala, A, Ballardini, G, Briganti, E, Magnani, G, Ursitti, MA, Arlotti, M, Ortolani, P, Ortona, L, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Del Forno, L, Zaccarelli, M, Acinapura, R, De Longis, P, Ciardi, M, D'Offizi, G, Trotta, MP, Noto, P, Lichtner, M, Capobianchi, MR, Girardi, E, Pezzotti, P, Rezza, G, Mura, MS, Mannazzu, M, Caramello, P, Sinicco, A, Soranzo, ML, Gennero, L, Sciandra, M, Bonasso, M, Grossi, PA, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, De Lalla, F, Tositti, G, Resta, F, Chimienti, A, and Cozzi-Lepri, A

Abstract

We examined the impact of a lamivudine-containing highly active antiretroviral therapy (HAART) regimen on 164 hepatitis B virus/HIV co-infected individuals starting their first HAART. Lamivudine-treated patients (accounting for 73% of the study population) showed a significantly lower level of alanine aminotransferase over follow-up [–81.1 mU/ml mean difference; 95% confidence intervals (95% CI): –30.3; –131.7, P=0.003] and a significantly reduced risk of liver-related morbidity/mortality [Relative hazard (RH)=0.07; 95% CI: 0.01–0.38, P=0.002] than those starting a lamivudine sparing-regimen.

Published
2004
Full Text
View/download PDF

4. Variability in the Interpretation of Transmitted Genotypic HIV-1 Drug Resistance and Prediction of Virological Outcomes of the Initial Haart by Distinct Systems

Author

Luca, Andrea De, Cozzi-Lepri, Alessandro, Perno, Carlo-Federico, Balotta, Claudia, Giambenedetto, Simona Di, Poggio, Antonio, Pagano, Gabriella, Tositti, Giulia, Piscopo, Rita, Forno, Antonio Del, Chiodo, Francesco, Magnani, Giacomo, Monforte, Antonella d'Arminio, Angarano, G, Antinori, A, Balotta, C, Cozzi-Lepri, A, Monforte, A d'Arminio, De Luca, A, Monno, L, Perno, CF, Rusconi, S, Montroni, M, Scalise, G, Zoli, A, Del Prete, MS, Tirelli, U, Di Gennaro, G, Pastore, G, Ladisa, N, Minafra, G, Suter, F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cadeo, GP, Castelli, F, Minardi, C, Vangi, D, Rizzardini, G, Migliorino, G, Manconi, PE, Piano, P, Ferraro, T, Scerbo, A, Pizzigallo, E, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Galloni, D, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Caputo, S Lo, Angarano, G, Grisorio, B, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Piersantelli, N, Alessandrini, A, Piscopo, R, Toti, M, Chigiotti, S, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Fibbia, G, Moroni, M, Lazzarin, A, Cargnel, A, Vigevani, GM, Caggese, L, d'Arminio Monforte, A, Repetto, D, Novati, R, Galli, A, Merli, S, Pastecchia, C, Moioli, MC, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Izzo, C, Piazza, M, De Marco, M, Montesarchio, V, Manzillo, E, Graf, M, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Balzelli, F, Loso, K, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, Gala, A La, Ballardini, G, Briganti, E, Magnani, G, Ursitti, MA, Arlotti, M, Ortolani, P, Cauda, R, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Di Giambenedetto, S, Zaccarelli, M, Acinapura, R, De Longis, P, Ciardi, M, D'Offizi, G, Trotta, MP, Noto, P, Lichtner, M, Capobianchi, MR, Girardi, E, Pezzotti, P, Rezza, G, Mura, MS, Mannazzu, M, Caramello, P, Sinicco, A, Soranzo, ML, Gennero, L, Sciandra, M, Bonasso, M, Grossi, PA, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, De Lalla, F, Tositti, G, Resta, F, Chimienti, A, and Lepri, A Cozzi

Abstract

High level HIV-1 drug resistance in recently infected treatment-naive individuals correlates with sub-optimal virological responses to highly active antiretroviral therapy (HAART). To determine whether genotypic HIV-1 drug resistance in chronic naive patients, as interpreted by various systems, could predict the virological outcomes of HAART, isolates from patients enrolled in a prospective observational cohort (ICoNA) prior to treatment start were genotyped. Genotypic susceptibility scores (GSS) assigned to the initial HAART regimens using the interpretations of pre-therapy resistance mutations by 13 systems were related to virological outcomes. Of 415 patients, 42 (10%) had at least one major resistance mutation. According to the different interpretations, 1.9–20.5% of patients had some level of resistance to at least one drug in the initial regimen. In multivariable analysis, GSS from two systems significantly predicted the time to virological success: Rega 5.5, for each unit increase in GSS adjusted relative hazard (RH) 1.86 [95% confidence intervals (95% CI): 1.15–3.02] and hivresistanceWeb v3, RH 1.87 (95% CI: 1.00–3.48). With three other systems, GSS showed a trend towards a significant prediction of success: Retrogram 1.6, RH 2.33 (95% CI: 0.98–5.53), Menéndez 2002, RH 2.36 (95% CI: 0.97–5.72) and Stanford hivdb, RH 2.06 (95% CI: 0.94–4.49). Genotypic resistance testing coupled with adequate interpretation in chronic naive patients can usefully identify those at risk of sub-optimal virological response to HAART.

Published
2004
Full Text
View/download PDF

5. Impact of Mutations Conferring Reduced Susceptibility to Lamivudine on the Response to Antiretroviral Therapy

Author

Perno, Carlo Federico, Cozzi-Lepri, Alessandro, Balotta, Claudia, Forbici, Federica, Violin, Michela, Bertoli, Ada, Facchi, Guido, Pezzotti, Patrizio, Angarano, Gioacchino, Arici, Claudio, Narciso, Pasquale, Orani, Anna, Raise, Enzo, Scalzini, Alfredo, Poggio, Antonio, Ippolito, Giuseppe, Moroni, Mauro, Monforte, Antonella d'Arminio, Montroni, M, Scalise, G, Costantini, A, Del Prete, MS, Tirelli, U, Nasti, G, Pastore, G, Perulli, LM, Suter, F, Arici, C, Chiodo, F, Gritti, FM, Colangeli, V, Fiorini, C, Guerra, L, Carosi, G, Cadeo, GP, Castelli, F, Minardi, C, Vangi, D, Rizzardini, G, Migliorino, G, Manconi, PE, Piano, P, Ferraro, T, Cosco, L, Pizzigallo, E, Ricci, F, Vigevani, GM, Pusterla, L, Carnevale, G, Pan, A, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Ambu, S, Lo Caputo, S, Angarano, G, Grisorio, B, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Piersantelli, N, Alessandrini, A., Piscopo, R., Toti, M, Chigiotti, Soscia, F, Tacconi, L, Orani, A, Castaldo, G, Scasso, A, Vincenti, A, Scalzini, A, Alessi, F, Moroni, M, Lazzarin, A, Cargnel, A, Milazzo, F, Caggese, L, Monforte, A d'Arminio, Melzi, S, Delfanti, F, Carini, B, Adriani, B, Garavaglia, S, Moioli, C, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Perrella, O, Piazza, M, De Marco, M, Montesarchio, V, Manzillo, E, Nappa, S, Cadrobbi, P, Scaggiante, R, Colomba, A, Abbadesse, V, Prestileo, T, Mancuso, S, Filice, G, Minoli, L, Savino, FA Patruno, Maserati, R, Pauluzzi, S, Baldelli, F, Petrelli, E, Ciotti, A, Alberici, F, Sisti, M, Menichetti, F, Smorfa, A, De Stefano, C, La Gala, A, Zauli, T, Ballardini, G, Bonazzi, L, Ursitti, MA, Ciammarughi, R, Giordani, S, Ortona, L, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Del Forno, A, Zaccarelli, M, De Longis, P, Ciardi, M, D'Offizi, G, Palmieri, F, Lichter, M, Capobianchi, MR, Girardi, E, Pezzotti, P, Rezza, G, Mura, MS, Mannazzu, M, Caramello, P, Sinicco, A, Soranzo, ML, Quaglia, S, Sciandra, M, Salassa, B, Torre, D, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, De Lalla, F, Tositti, G, Resta, F, Chimienti, A, Lepri, A Cozzi, and Phillips, AN

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results