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The potential of Lactobacillus rhamnosus GG to reduce aflatoxin [B.sub.1] (AF[B.sub.1]) availability in vitro in Caco-2 cells was investigated. Results suggested that (AF[B.sub.1]) transport can be reduced by GG binding in the Caco-2 model, while these Caco-2 cells can be used to estimate the intestinal metabolism and toxicity of (AF[B.sub.1]) by use of TER measurements.

The modulation of aflatoxin B1 (AFB1) uptake in rats by administration of the probiotic Lactobacillus rhamnosus GG is demonstrated. Fecal AFB1 excretion in GG-treated rats is increased through bacterial AFB1 binding.

Studies done to determine whether AFB1 and intestinal mucus influence each otherEs binding by surface structures of two probiotic preparations are reported. The results reveal that probiotics adhering to the intestinal wall are less likely to bind and consequently accumulate AFB1 in the host and on the other hand probiotics with AFB1 bound to their surfaces are less likely to adhere to the intestinal wall and prolong expose to dietary AFB1. It is concluded that specific probiotics may be potent and safe means to reduce absorption and increase excretion of dietary AFB1 from the body.