1. Identification of DysI, the immunity factor of the streptococcal bacteriocin dysgalacticin
- Author
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Gregory M. Cook, John R. Tagg, Pearl M. Swe, Nicholas C. K. Heng, and Ralph W. Jack
- Subjects
Transcription, Genetic ,Operon ,Molecular Sequence Data ,Genetics and Molecular Biology ,Microbial Sensitivity Tests ,Biology ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Microbiology ,Plasmid ,Bacteriocin ,Bacterial Proteins ,Bacteriocins ,Immunity ,medicine ,Amino Acid Sequence ,Peptide sequence ,Ecology ,Streptococcus ,Glucose transporter ,Anti-Bacterial Agents ,Genes, Bacterial ,bacteria ,Intracellular ,Food Science ,Biotechnology ,Plasmids - Abstract
DysI is identified as the protein that confers specific immunity to dysgalacticin, a plasmid-encoded streptococcal bacteriocin. dysI is transcribed as part of the copG - repB - dysI replication-associated operon. DysI appears to function at the membrane level to prevent the inhibitory effects of dysgalacticin on glucose transport, membrane integrity, and intracellular ATP content.
- Published
- 2010