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Numerous novel concepts in fractional mathematics have been created to provide numerical models for a variety of real-world, engineering, and scientific challenges because of the kernel’s memory and non-local effects. In this post, we have looked at a deadly illness known as rabies. For our analysis, we employed the Atangana–Baleanu fractional derivative in Caputo sense. Additionally, the mathematical answer was obtained by applying the Laplace transform. Our approach is distinct, and we illustrated the vital role immunizations play in limiting the spread of the illness using graphical data. Furthermore, in this article, we have shown that fractional order systems are preferable to integer order systems. [ABSTRACT FROM AUTHOR]