1. Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia
- Author
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Fu, Ying-Kai, Chang, Chia-Jung, Chen, Kuan-Yin, Hwang, Li-Chung, Wu, Kuo-Hung, Chang, Kang-Wei, Jan, Meei-Ling, Chen, Chia-Chieh, and Chang, Chih-Hsien
- Subjects
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CEREBRAL ischemia , *POSITRON emission tomography , *LABORATORY rats , *ARTERIAL occlusions , *ANIMAL disease models , *CEREBRAL arteries , *HEALTH outcome assessment , *BRAIN imaging , *DIAGNOSIS ,BRAIN metabolism - Abstract
Abstract: Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents. [Copyright &y& Elsevier]
- Published
- 2009
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