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Abstract We developed a new apparatus for the routine production of 64Cu in clinical use. The apparatus has many disposable parts that stabilize the product quality (such that there is a low deviation of the concentrations of impurity metals in the product) and reduce the work load of preparation for routine production. We also developed a new evaporator using near-infrared heaters for disposable use. We conducted a production test using the new apparatus and evaluated product quality. The product yield was 6.3 ± 0.32 GBq (end of bombardment) (N = 4), the product quality in terms of the concentrations of impurity metals (Cu2+, Ni2+, Fe3+, Zn2+, Mn2+) was as good as that usually achieved, likely on the order of parts per billion, and the preparation time was reduced from 2 days to 1 day. Highlights • An easy-handling separation system was developed using many disposable parts. • The concentration of impurity metals was likely on the order of parts per billion. • This quality was as good as that of our usually obtained product. • A new disposable evaporator was developed using a near-infrared heater. • The preparation time was reduced from 2 days to 1 day. [ABSTRACT FROM AUTHOR]