Search

Your search keyword '"Guaifenesin analogs & derivatives"' showing total 1 results
Start Over Descriptor "Guaifenesin analogs & derivatives" Journal applied radiation and isotopes including data instrumentation and methods for use in agriculture industry and medicine

Refine your results

1 results on '"Guaifenesin analogs & derivatives"'

1. Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration.

Author

Yeong CH, Blackshaw PE, Ng KH, Abdullah BJ, Blaauw M, Dansereau RJ, and Perkins AC

Subjects
Administration, Oral, Guaifenesin administration & dosage, Humans, Isotope Labeling, Neutron Activation Analysis, Radioisotopes, Reproducibility of Results, Samarium, Guaifenesin analogs & derivatives
Abstract

Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86±0.03 MBq. Good reproducibility (CV=3.5%) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results