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A screen-printed electrode modified with zirconium antimonate ionophore was fabricated for the quantification of Hg(II) ion. The modified electrode revealed linear response in a wide concentration range of 5 × 10−8-1 × 10−1 mol/L at 25 °C of Hg(II) with a slope of 30.02 ± 0.75 mV/decade with detection limit of 5 × 10−8 mol/L. The electrode can be used in the pH range 2.5-8.5. Selectivity coefficients were assessed using fixed interference and matched potential techniques. The electrode stability was maintained for 16 weeks. This modified electrode was allowed to determine Hg(II) ions in different media such as water, dental amalgam and fish tissue. An inductively coupled plasma-optical emission spectrometry confirmed the efficiency and accuracy of the nominated modified electrode. [ABSTRACT FROM AUTHOR]