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Start Over Author "Goetz, Giles W." Journal aquatic toxicology
1 results on '"Goetz, Giles W."'

1. High-throughput sequencing and pathway analysis reveal alteration of the pituitary transcriptome by 17α-ethynylestradiol (EE2) in female coho salmon, Oncorhynchus kisutch.

Author

Harding, Louisa B., Schultz, Irvin R., Goetz, Giles W., Luckenbach, J. Adam, Young, Graham, Goetz, Frederick W., and Swanson, Penny

Subjects
*HIGH throughput screening (Drug development), *PITUITARY gland, *ETHINYL estradiol, *COHO salmon, *ONCORHYNCHUS, *RNA, *NUCLEOTIDE sequence
Abstract

Highlights: [•] Studied impacts of ethynylestradiol (EE2) exposure on salmon pituitary transcriptome. [•] High-throughput sequencing, RNAseq, and pathway analysis were performed. [•] EE2 altered mRNAs for genes in circadian rhythm, GnRH, and TGFβ signaling pathways. [•] LH and FSH beta subunit mRNAs were most highly up- and down-regulated by EE2, respectively. [•] Estrogens may alter processes associated with reproductive timing in salmon. [ABSTRACT FROM AUTHOR]

Published
2013
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