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Historical masonry structures are the most important features that distinguish our cultural heritage, from here comes the importance of protection this type of masonry structures from collapse under earthquakes effect or other dynamic loading such as blast loading. Therefore, Seismic Base Isolation is used to reduce earthquakes damages and protect structures from collapse. This paper aims to study the Effect of Seismic Base Isolation, using High Damping Rubber Bearing (HDRB) on Existing Masonry Structures subjected to dynamic loads such as earthquakes, through utilizing numerical modeling of masonry structures. This paper includes definition of seismic base isolation mechanical characteristics, and definition of numerical modeling approaches for structural masonry analysis. The studied masonry structure is the old AWQAF Directorate Building in Aleppo, which is islamic government building affiliated to the Syrian Ministry of AWQAF; In order to perform the numerical modeling, equivalent masonry properties used for this structure were also determined. This structure was analyzed applying nonlinear dynamic analysis-time history method, and reanalyzing it by using seismic base isolation, type HDRB applying the same method. The results of the two analyses were discussed and compared, and the conclusions of this paper showed reduction in shear force when using seismic base isolation, and reduction in stresses that appear in structure because the stresses are located in the level of base isolation system. [ABSTRACT FROM AUTHOR]