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Crumb rubber concrete (CRC) is a cementitious composite produced by incorporating rubber crumbs into normal concrete (NC), characterized by large deformation, high damping, high energy absorption, and lower Young's modulus than normal concrete. This article presents a study on the seismic performance of frame structures under four scenarios: one normal concrete frame and three CRC frames. The total lateral stiffness, fundamental period, lateral earthquake loading, and interstory lateral displacements are calculated and compared based on the standardized design procedure. The results indicate that CRC frame structures increase the fundamental period and reduce the lateral earthquake loadings. The fundamental period of the CRC columns and beams (S3) is increased by 5.48% against normal concrete beams and columns (S0). However, decrease in the total lateral stiffness and increase the interstory lateral displacements was observed. The lateral earthquake loading is reduced by more than 4% against S0. These two competing factors determine the plausibility and benefit of CRC in structural application regarding earthquake design. The inter-story lateral displacements of CRC structures are still within the permissible design limits, confirming CRC's plausibility in structural application. This study also lays the technical ground for further exploring CRC in concrete structural applications that may recycle large quantities of scrap automobile tires. [ABSTRACT FROM AUTHOR]