1. A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives.
- Author
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Ghoneim MM, Abdelgawad MA, Elkanzi NAA, Parambi DGT, Alsalahat I, Farouk A, and Bakr RB
- Subjects
- Humans, Structure-Activity Relationship, Drug Design, Animals, Molecular Structure, Quinazolines pharmacology, Quinazolines chemical synthesis, Quinazolines chemistry, Quinazolinones pharmacology, Quinazolinones chemical synthesis, Quinazolinones chemistry, Molecular Docking Simulation
- Abstract
Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in developing novel drug candidates owing to their pharmacological potential. They are important chemicals for the synthesis of a variety of physiologically significant and pharmacologically useful molecules. Quinazoline and quinazolinone derivatives have anticancer, anti-inflammatory, antidiabetic, anticonvulsant, antiviral, and antimicrobial potential. The increased understanding of quinazoline and quinazolinone derivatives in biological activities provides opportunities for new medicinal products. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, structure-activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives to help in the development of new quinazoline and quinazolinone derivatives., (© 2024 Deutsche Pharmazeutische Gesellschaft.)
- Published
- 2024
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