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39 results on '"Vanhoutte PM"'

1. Inhibition of norepinephrine uptake by potassium ions in vascular smooth muscle.

Author

Vanhoutte PM and Lorenz RR

Subjects
Animals, Cocaine pharmacology, Depression, Chemical, Dogs, Electric Stimulation, In Vitro Techniques, Muscle Contraction drug effects, Muscle, Smooth drug effects, Norepinephrine antagonists & inhibitors, Saphenous Vein metabolism, Tritium, Muscle, Smooth metabolism, Norepinephrine metabolism, Potassium pharmacology
Published
1974

7. Serotonergic responses in vascular and non-vascular tissues.

Author

Van Nueten JM, Leysen JE, Vanhoutte PM, and Janssen PA

Subjects
Animals, Guinea Pigs, In Vitro Techniques, Muscle Contraction drug effects, Muscle, Smooth, Vascular drug effects, Rats, Serotonin Antagonists pharmacology, Muscle, Smooth physiology, Muscle, Smooth, Vascular physiology, Serotonin physiology
Published
1982

8. Effect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation.

Author

Rusch NJ, De Mey JG, and Vanhoutte PM

Subjects
Animals, Cocaine antagonists & inhibitors, Dogs, Dose-Response Relationship, Drug, Drug Antagonism, Estradiol, Estrogen Antagonists, In Vitro Techniques, Norepinephrine antagonists & inhibitors, Prazosin analogs & derivatives, Propranolol antagonists & inhibitors, Saphenous Vein physiology, Muscle Contraction drug effects, Muscle, Smooth, Vascular physiology, Phentolamine pharmacology, Prazosin pharmacology, Quinazolines pharmacology, Sympathomimetics antagonists & inhibitors
Published
1980

9. Cocaine and contractile responses of vascular smooth muscle from spontaneously hypertensive rats.

Author

Webb RC and Vanhoutte PM

Subjects
Animals, Electric Stimulation, Male, Norepinephrine metabolism, Norepinephrine pharmacology, Rats, Rats, Inbred Strains, Cocaine pharmacology, Hypertension physiopathology, Muscle Contraction drug effects, Muscle, Smooth, Vascular drug effects
Abstract

The goal of this study was to compare the effects of cocaine on contractile responses of isolated vascular smooth muscle from spontaneously hypertensive (SHR) and normotensive rats. Helical strips of tail artery from adult SHR and normotensive rats were mounted in organ chambers between two platinum wire electrodes; isometric contractions were recorded. Vascular responsiveness was determined before and after acute denervation with 6-hydroxydopamine or before and after treatment with cocaine. Cumulative addition of cocaine (10(-10) to 10(-3)M) produced contraction of the strips. SHR was found to be les sensitive to cocaine than normotensive rats. Contractions induced by cocaine were blocked by phentolamine and reduced after acute denervation. The sensitivity to exogenous norepinephrine (3 X 10(-12) to 3 X 10(-5)M) and contractile responses to electrical stimulation (0.1 to 16 Hz) of innervated strips were similar for SHR and normotensive rats. Cocaine (10(-6)M) potentiated contractile responses to norepinephrine and electrical stimulation. The magnitude of potentiation to norepinephrine and to electrical stimulation was greater in SHR than in normotensive rats. Cocaine (10(-6) M) produced relaxation of strips contracted with tyramine (10(-4) M). The magnitude of relaxation induced by cocaine was less in SHR than in normotensive rats. The uptake of 3H-norepinephrine was greater in tail arteries isolated from SHR as compared to those from normotensive rats. Cocaine (10(-4)M) inhibited the uptake of 3H-norepinephrine in both groups of rats. The magnitude of inhibition was greater in SHR. These results suggest that the neuronal uptake pump in blood vessels from SHR is more efficient than that in normotensive rats.

Published
1981

12. Acetylcholine inhibits potassium evoked release of 3H-norepinephrine in different blood vessels of the dog.

Author

Verbeuren TJ and Vanhoutte PM

Subjects
Animals, Blood Vessels drug effects, Depression, Chemical, Dogs, In Vitro Techniques, Mesenteric Veins metabolism, Norepinephrine antagonists & inhibitors, Pulmonary Artery drug effects, Regional Blood Flow drug effects, Saphenous Vein drug effects, Tibia blood supply, Acetylcholine pharmacology, Blood Vessels metabolism, Norepinephrine metabolism, Potassium pharmacology
Published
1976

18. Contribution of the endothelium to the response to anoxia in the canine femoral artery.

Author

De Mey JG and Vanhoutte PM

Subjects
Animals, Dogs, Endothelium physiology, Femoral Artery physiopathology, In Vitro Techniques, Muscle, Smooth, Vascular drug effects, Norepinephrine pharmacology, Arteries physiopathology, Hypoxia physiopathology, Muscle Contraction drug effects, Muscle, Smooth, Vascular physiopathology
Published
1981

22. Effect of temperature on drug-receptor interaction in isolated canine veins.

Author

Janssens WJ and Vanhoutte PM

Subjects
Animals, Cocaine pharmacology, Dogs, Drug Interactions, Femoral Vein drug effects, In Vitro Techniques, Muscle Contraction drug effects, Muscle, Smooth drug effects, Phentolamine pharmacology, Propranolol pharmacology, Saphenous Vein drug effects, Temperature, Norepinephrine pharmacology, Receptors, Adrenergic drug effects, Veins drug effects
Published
1977

23. Inhibition by catecholamines of cholinergic neurotransmission in canine bronchi in vitro.

Author

Vermeire PA and Vanhoutte PM

Subjects
Animals, Atropine pharmacology, Bronchi drug effects, Depression, Chemical, Dogs, Hexamethonium Compounds pharmacology, In Vitro Techniques, Isoproterenol pharmacology, Muscle Contraction drug effects, Muscle, Smooth drug effects, Norepinephrine pharmacology, Phentolamine pharmacology, Propranolol pharmacology, Terbutaline pharmacology, Tetrodotoxin pharmacology, Verapamil pharmacology, Bronchi innervation, Catecholamines pharmacology, Parasympathetic Nervous System drug effects, Synaptic Transmission drug effects
Published
1977

26. Effect of potassium on the mechanical activity of rat tail artery.

Author

Webb RC, Vanhoutte PM, and Bohr DF

Subjects
Animals, Arteries drug effects, Electric Stimulation, In Vitro Techniques, Male, Muscle Contraction drug effects, Muscle, Smooth drug effects, Rats, Tail blood supply, Potassium pharmacology, Vasoconstriction drug effects
Published
1978

29. Differences in pharmacological properties of postjunctional alpha-adrenergic receptors among arteries and veins.

Author

De Mey JG and Vanhoutte PM

Subjects
Animals, Dogs, In Vitro Techniques, Methoxamine pharmacology, Norepinephrine pharmacology, Phenylephrine pharmacology, Prazosin pharmacology, Yohimbine pharmacology, Arteries physiology, Muscle Contraction drug effects, Muscle, Smooth, Vascular physiology, Receptors, Adrenergic physiology, Receptors, Adrenergic, alpha physiology, Veins physiology
Published
1980

30. Effect of Ca2+-entry blockade and serotonergic antagonism on contractions of hypoxic isolated canine coronary arteries.

Author

Van Nueten JM, Van Beek J, and Vanhoutte PM

Subjects
Animals, Dogs, In Vitro Techniques, Calcium Channel Blockers pharmacology, Coronary Vessels drug effects, Hypoxia physiopathology, Serotonin Antagonists pharmacology, Vasoconstriction drug effects
Abstract

Lidoflazine, flunarizine, and R 51 469 antagonized contractions of isolated canine coronary arteries caused by depolarizing solution or 5-hydroxytryptamine, and the further increase in tension caused by hypoxia during such contractions. The 5-HT2-antagonist ketanserin, but not methysergide, antagonized contractions induced by 5-hydroxytryptamine, but not those by high K+; it reduced further increases in tension caused by hypoxia only during contractions caused by 5-hydroxytryptamine. Augmentation by hypoxia of coronary vasoconstriction appears to be a Ca2+-dependent phenomenon.

Published
1983

39. Effect of cooling on beta-receptor mechanisms in isolated saphenous veins of the dog.

Author

Vanhoutte PM and Shepherd JT

Subjects
Acetylcholine pharmacology, Adrenergic alpha-Agonists pharmacology, Adrenergic alpha-Antagonists pharmacology, Animals, Dogs, Norepinephrine pharmacology, Phentolamine pharmacology, Saphenous Vein drug effects, Cold Temperature, Isoproterenol pharmacology, Muscle Contraction, Vasomotor System physiology, Veins drug effects
Published
1970

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