1. On the antagonism of isopropylnoradrenaline towards sympathetic mediators. A Study on the Rat's Blood Pressure
- Author
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D. Della Bella, F. Rognoni, and U. M. Teotino
- Subjects
medicine.medical_specialty ,Physiology ,Blood Pressure ,Biochemistry ,Hypotensive action ,Basal (phylogenetics) ,Hostility ,In vivo ,Internal medicine ,Pressure ,Animals ,Medicine ,Sympathomimetics ,skin and connective tissue diseases ,Adrenergic blocking ,business.industry ,Direct effects ,Isoproterenol ,Blood Pressure Determination ,Rats ,respiratory tract diseases ,β receptor ,Blood pressure ,Endocrinology ,business ,Antagonism - Abstract
In the « in vivo » experiments on the rat blood pressure both direct effects of isopropylnoradrenaline (IPA) and its influence on the responses to adrenaline (A) and noradrenaline (NA) have been studied.The hypotensive action of IPA resulted only partially dependent on the doses given and was not observed with basal pressures as low as 50 mm. Hg. In contrast to what has been postulated for the dog, the hypotensive effect of IPA was not reversed — in the rat — by pretreatment with adrenergic blocking agents.In agreement with earlier results, IPA was shown to exert an evident antagonistic action both at the α and β receptors level : reducing hypertension by A and NA and modifying the responses to A and NA of the rat isolated aorta strip at the former, and inhibiting the « reversed » response to A in the animal pretreated with an adrenergic blocking agent at the latter.
- Published
- 1962
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