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Honeybee products including bee pollen (BP) have been a topic of interest by medical professionals for a long time. Recently, many studies revealed many natural compounds in BP that has a huge potential to express many therapeutic activities. Although in vivo studies are too few, there is wide variability on BP compounds due to several factors such as geographic and climate conditions, and there is a lack of standardization for the studies; nutritious, anti-microbial, anti-mutagenic, antioxidant, anti-inflammatory, anti-atherosclerotic, hypolipidemic, hypoglycemic, fibrinolytic effects and inhibitor activity to platelet aggregation were observed. So, BP holds the potential of being a major therapeutic agent, and to be a topic of medical scientific research. [ABSTRACT FROM AUTHOR]