1. Sperm DNA integrity: correlation with sperm plasma membrane integrity in semen evaluated for male infertility
- Author
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J. B. M. Mullen, Sergey I. Moskovtsev, Azar Azad, and Jennifer Willis
- Subjects
Adult ,Male ,urogenital system ,Sperm membrane ,Cell Membrane ,Sperm dna ,Semen ,DNA ,Biology ,Middle Aged ,medicine.disease ,Spermatozoa ,Male infertility ,Correlation ,Andrology ,Endocrinology ,Human fertilization ,medicine ,DNA fragmentation ,Humans ,Infertility, Male ,Sperm plasma membrane - Abstract
Previous independent studies have indicated that abnormally low parameters of sperm DNA integrity and sperm membrane integrity correlate to reduced fertility due in part to implantation disorders. The purpose of our study was to evaluate the relationship between sperm plasma membrane functional integrity assessed by the hypo-osmotic swelling test (HOST) and sperm DNA integriy test assesed by DNA fragmentation index (DFI). Semen samples from 102 random patients were evaluated in terms of standard semen parameters and assessed by DFI and HOST. Both tests showed a significant correlation to standard semen parameters (p
- Published
- 2005