1. Distribution of lipid aldehydes in phase-separated membranes: A molecular dynamics study.
- Author
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Oliveira, Maria C., Yusupov, Maksudbek, Bogaerts, Annemie, and Cordeiro, Rodrigo M.
- Subjects
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LIPID rafts , *MOLECULAR dynamics , *MEMBRANE lipids , *ALDEHYDES , *CELL membranes , *CELL permeability - Abstract
It is well established that lipid aldehydes (LAs) are able to increase the permeability of cell membranes and induce their rupture. However, it is not yet clear how LAs are distributed in phase-separated membranes (PSMs), which are responsible for the transport of selected molecules and intracellular signaling. Thus, we investigate here the distribution of LAs in a PSM by coarse-grained molecular dynamics simulations. Our results reveal that LAs derived from mono-unsaturated lipids tend to accumulate at the interface between the liquid-ordered/liquid-disordered domains, whereas those derived from poly-unsaturated lipids remain in the liquid-disordered domain. These results are important for understanding the effects caused by oxidized lipids in membrane structure, properties and organization. [Display omitted] • Liquid-ordered (Lo) and liquid-disordered (Ld) phases coexist in cell membranes (lipid rafts). • The interface between the Lo/Ld domains is more susceptible to pore formation. • Lipid aldehydes (LAs) derived from mono-unsaturated lipids tend to accumulate at the interface between the Lo/Ld domains. • LAs derived from poly-unsaturated lipids remains in the Ld domain. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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