1. Where is the vitamin D receptor?
- Author
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Wang, Yongji, Zhu, Jinge, and DeLuca, Hector F.
- Subjects
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VITAMIN D receptors , *PHYSIOLOGICAL effects of phosphates , *PHYSIOLOGICAL effects of calcium , *CELL differentiation , *CELL proliferation , *PATHOLOGICAL physiology - Abstract
Abstract: The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body. [Copyright &y& Elsevier]
- Published
- 2012
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