1. Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I
- Author
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Genova, Maria Luisa, Abd-Elsalam, Nagwa M., Mahdy, El Sayed M.E., Bernacchia, Andrea, Lucarini, Marco, Pedulli, Gian Franco, and Lenaz, Giorgio
- Subjects
- *
MEDICAL research , *OXIDATION-reduction reaction , *ADRENALINE , *SUPEROXIDES - Abstract
Abstract: Complex I in bovine heart submitochondrial particles catalyses the NADH-supported generation of superoxide anion; adrenaline is oxidised by superoxide to adrenochrome that, on its hand, is reduced by Complex I, thus establishing a redox cycle that amplifies the superoxide production. The routes in Complex I for superoxide formation and for adrenochrome reduction appear to be different, since they have a different sensitivity to Complex I inhibitors. The results are discussed in terms of current assays for superoxide detection and of pathologies linked to catecholamine oxidation. [Copyright &y& Elsevier]
- Published
- 2006
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