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BackgroundContrast induced nephrotoxicity (CIN) after coronary angiography or angioplasty (CA) has been shown to be related to mortality. The rate and predictors of CIN when preventive measures are applied are poorly documented.MethodsAll consecutive patients submitted to non-urgent CA in 2014 with low-osmolar contrast medium were stratified for CIN risk: patients with renal dysfunction (defined as eGFR44mmol/L in SCr. CIN rate was related to quartiles of eGFR before CA: 20% when eGFR87ml/min. The amount of contrast medium was not a predictor of CIN. In patients without renal dysfunction, a lower SCr was a predictor of CIN. Conversely, in patients with renal dysfunction, older age and diabetes were associated with CIN (figure).ConclusionsIn contemporary routine practice, CIN occurs in 20%, driven by a relative 25% increase in SCr, and irrespective of the amount of contrast medium. In patients with renal dysfunction, older age and diabetes were associated with CIN.

Rationale and aim Introduced in early 2000, Fractional Flow Reserve (FFR) was initially validated for deferring percutaneous coronary intervention (PCI) when >0.80. After September 2012, FAME2 suggested performing PCI when FFR Methods Rate and indications of FFR use and decision for PCI was assessed monthly between April 1999 and Sept 2014 in a single center. We calculated monthly the rates of FFR, coronary angiography (CA) and PCI. Cumulative curves for CA, PCI and FFR we determined the according to time elapsed since 1999. Results In a single center, 26629 CA, 12270 PCI and 2454 FFR were performed between 1999 and 2014. Monthly rates were 182 CA, 77 PCI and 14 FFR. The cumulative curves showed that the rates of CA and PCI were stable, with a near-perfect linear correlation for each time interval. Conversely, there was a change in the rate of FFR, the best spline point for the FFR use was found in September 2012. From 1999 to Sept 2012, the rate of FFR was 14/month and increased to 21/month after Sept 2012. There was no significant difference in the patient characteristics, indications for CA or center team or equipment between the 2 periods, but the rate of FFR/CA increased from 7.3 to 12%. Conclusion Physicians performed more FFR after Sept 2012. This increase in routine use of FFR was only explained by the additional indication for FFR resulting from the publication of the FAME2 study. Download : Download high-res image (170KB) Download : Download full-size image Abstract 0301 – Figure

BackgroundWe investigated the course of residual pulmonary vascular obstruction (RPVO) from discharge up to 3 – 6 months after pulmonary embolism (PE).MethodsProspective registry including 202 consecutive patients with PE who survived the acute phase (high risk PE: 12.4%, intermediate-risk: 65.8%, and low- risk: 21.8%). Patients with a prior history of chronic pulmonary disease were excluded. Ventilation-perfusion (V/Q) lung scan was performed in all patients before discharge, and again at follow-up (between 3 and 6 months after discharge). Treatment was in accordance with current guidelines. Evolution of RPVO was determined as the relative change in lung perfusion (in %) between discharge and follow-up V/Q scans.ResultsBetween both lung scans, RPVO decreased from 29.1±15% to 10.9±11.4%, with an average relative change of 61.7±33.4%. Overall, 49 patients (24.2%) presented a full resolution of lung perfusion. Relative change in RPVO was