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Background In euthyroid healthy adults thyroid function is known to be associated with obesity, insulin resistance, glycaemia, and dyslipidaemia. Little is known of similar associations in pregnancy, where maternal subclinical hypothyroidism or hypothyroxinaemia can have a detrimental effect on both mother and fetus.1 Aims To assess the associations between reduced thyroid function (subclinical hypothyroidism/ hypothyroxinaemia), and maternal metabolic parameters in a non-diabetic Caucasian pregnant population. Methods Detailed anthropometry and fasting biochemistry was obtained on 965 euthyroid Caucasian women with singleton, non-diabetic pregnancies recruited at 28 weeks gestation into the Exeter Family Study of Childhood Health (EFSOCH)2 Thyroid function tests (TSH, FT4 and FT3) and TPO antibodies were measured. Trimester specific reference ranges were identified.(3) We assessed the maternal metabolic parameters (BMI, FPG, triglycerides and insulin resistance (IR)) of those with and without mildly reduced thyroid function. Results 82 women had hypothyroxinaemia (FT4 3.mlU/l). There was no difference in the metabolic parameters between those with and without subclinical hypothyroidism. Women with hypothyroxinaemia had higher BMI (29.8 (25.3–35.0) vs. 27.4(23.5–31.9), p Conclusion Our study has identified that hypothyoxinaemia is associated with an altered metabolic profile. These findings may have implications for clinical care. References Breathnach FM, Donnelly J, Cooley SM, Geary M, Malone FD. Subclinical hypothyroidism as a risk factor for placental abruption: evidence from a low-risk primigravid population. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2013 Dec;53(6):553–60 Knight B, Shields BM, and Hattersley AT. The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology. Paediatric Perinatal Epidemiology 2006;20(2):172–9

Background Recent studies from India have suggested that low vitamin B12 ( 1 These associations may not be present in a Western European Caucasian population, where micronutrient deficiencies are thought to be less common. Aims To assess the associations between maternal adiposity and insulin resistance (IR) and circulating serum B12 levels in a non-diabetic pregnant Caucasian population. Methods Detailed anthropometric measurements and biochemistry data were available on 995 women recruited as part of the Exeter Family Study of Childhood Health. 2 Height, weight, sum of skin-fold thickness (SS) and fasting bloods were taken at 28 weeks of pregnancy (+/-5 days). A subset of 567 women was followed up at 5 years post pregnancy. Results The geometric mean (standard deviation range) serum concentration of B12 was 201 (159–263) pmol/l. 198(20%) had B12 2 ), IR(1.6 vs1.2) Triglycerides (2.3 vs. 2.0 mmol/l) and SS (58.2 vs 50.2 mm), p 2 ), SS(54.6 vs 46.7mm), and IR(0.97 vs 0.68), p Conclusions Our study has replicated the Indian findings of associations between lower serum B12 during pregnancy and higher adiposity and insulin resistance in this non-diabetic Caucasian population. These associations may represent micronutrient deficiencies resulting from poor quality diet or absorption problems associated with obesity. These findings may have important implications for fetal and maternal health in obese pregnancies. References Krishnaveni GV, et al . Low plasma vitamin B12 in pregnancy is associated with gestational ‘diabesity’ and later diabetes. Diabetologia 52(11):2350–8 Knight B, Shields BM, and Hattersley AT. The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology. Paediatric Perinatal Epidemiology 2006;20(2):172–9