1. Selenium, oxidative stress and inflammatory markers in handicraft workers occupationally exposed to lead
- Author
-
Praveen Sharma, Gangam Saikiran, Prasenjit Mitra, Pvsn Kiran Kumar, and Shailja Sharma
- Subjects
Male ,medicine.medical_specialty ,Antioxidant ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,chemistry.chemical_element ,Inflammation ,Toxicology ,medicine.disease_cause ,Antioxidants ,chemistry.chemical_compound ,Selenium ,Internal medicine ,medicine ,Humans ,General Environmental Science ,chemistry.chemical_classification ,Reactive oxygen species ,medicine.diagnostic_test ,Interleukin-6 ,Public Health, Environmental and Occupational Health ,Malondialdehyde ,Male workers ,Oxidative Stress ,Endocrinology ,chemistry ,Lead ,Cytokines ,Blood lead level ,medicine.symptom ,Oxidative stress ,Biomarkers - Abstract
Occupational Lead (Pb) exposure increases reactive oxygen species and has been reported to impact inflammatory response by modulating intracellular signaling pathways. Selenium (Se) a vital component of the antioxidant system that plays an important role in modulating cytokines. The present study evaluated Se, malondialdehyde (MDA), total antioxidant capacity (TAC) and cytokines (IL-6, TNF-α, IL-10, IL-17a) in 81 Pb exposed male workers. The median (range) of blood lead level (BLL) and Se were 5 (0.50–31.76) µg/dL and 104 (46.9–189.6) µg/L respectively. The Se, TAC levels were decreased, and MDA, IL-6 levels were increased in the high Pb group (>5μg/dL). Blood lead level independently predicted oxidative stress and antioxidant status. Selenium, TAC levels negatively and MDA, IL-6 levels positively correlated with BLL. Association of Se with IL-6 and TAC suggests some probable role of Se in the underlined mechanism of Pb toxicity.
- Published
- 2021