1. Comparison between laparoscopic and abdominal radical hysterectomy for low-risk cervical cancer: a multicentre retrospective study.
- Author
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Li, Zhiqiang, Chen, Chunlin, Liu, Ping, Lu, Anwei, Zhao, Hongwei, Zhan, Xuemei, Duan, Hui, Li, Pengfei, Zhao, Weidong, Yao, Jilong, Li, Donglin, Jiang, Haixia, Liu, Mubiao, Bin, Xiaonong, and Lang, Jinghe
- Subjects
HYSTERECTOMY ,CERVICAL cancer ,LAPAROSCOPIC surgery ,PROPENSITY score matching ,PROGRESSION-free survival - Abstract
Purpose: To compare oncological outcomes of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for low-risk cervical cancer. Method: We retrospectively compared the 3-year overall survival (OS) and 3-year disease-free survival (DFS) of 1269 low-risk cervical cancer patients with FIGO 2009 stage IA2, IB1 and IIA1 with a tumour size < 2 cm, no lymphovascular space invasion (LVSI), superficial stromal invasion and no lymph node involvement on imaging, and who received LRH (n = 672) and ARH (n = 597) between 2009 and 2018 at 47 hospitals. Results: In the total study population, LRH and ARH showed similar 3-year OS (98.6% vs. 98.9%, P = 0.850) and DFS rates (95.7% vs. 96.4%, P = 0.285). LRH was not associated with worse 3-year OS (HR 0.897, 95% CI 0.287–2.808, P = 0.852) or DFS (HR 0.692, 95% CI 0.379–1.263, P = 0.230) as determined by multivariable analysis. After propensity score matching in 1269 patients, LRH (n = 551) and ARH (n = 551) still showed similar 3-year OS (98.4% vs. 98.8%, P = 0.704) and DFS rates (95.5% vs. 96.3%, P = 0.249). LRH was still not associated with worse 3-year OS (HR 0.816, 95% CI 0.262–2.541, P = 0.725) or DFS (HR 0.694, 95% CI 0.371–1.296, P = 0.251). Conclusion: Among patients with low-risk cervical cancers < 2 cm, no LVSI, superficial stromal invasion, and no lymph node involvement on imaging, no significant differences were observed in 3-year OS or DFS rates between LRH and ARH. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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