1. Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development.
- Author
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Martinez-Fierro, Margarita L., Garza-Veloz, Idalia, Gutierrez-Arteaga, Cristina, Delgado-Enciso, Ivan, Barbosa-Cisneros, Olga Y., Flores-Morales, Virginia, Hernandez-Delgadillo, Gloria P., Rocha-Pizaña, Maria R., Rodriguez-Sanchez, Iram P., Badillo-Almaraz, Jose I., Ortiz-Rodriguez, Jose M., Castañeda-Miranda, Rodrigo, Solis-Sanchez, Luis O., and Ortiz-Castro, Yolanda
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MICRORNA , *CHROMOSOMES , *PREECLAMPSIA , *PLACENTA , *NUCLEOTIDES - Abstract
Purpose: To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development. Methods: Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls ( n = 18) using TaqMan low density array plates. Results: A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, were differentially expressed between groups ( P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE ( P = 0.035) and WWD-Severe-PE ( P = 0.007). Conclusions: Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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