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10 results on '"Bulat, Zorica"'

2. In silicoanalysis of the impact of toxic metals on COVID-19 complications: molecular insights

Author

Živanović, Jovana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Marić, Đurđica, Miljaković, Evica Antonijević, Đorđević, Aleksandra Buha, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, and Đukić-Ćosić, Danijela

Abstract

COVID-19 can cause a range of complications, including cardiovascular, renal, and/or respiratory insufficiencies, yet little is known of its potential effects in persons exposed to toxic metals. The aim of this study was to answer this question with in silicotoxicogenomic methods that can provide molecular insights into COVID-19 complications owed to exposure to arsenic, cadmium, lead, mercury, nickel, and chromium. For this purpose we relied on the Comparative Toxicogenomic Database (CTD), GeneMANIA, and ToppGene Suite portal and identified a set of five common genes (IL1B, CXCL8, IL6, IL10, TNF) for the six metals and COVID-19, all of which code for pro-inflammatory and anti-inflammatory cytokines. The list was expanded with additional 20 related genes. Physical interactions are the most common between the genes affected by the six metals (77.64 %), while the dominant interaction between the genes affected by each metal separately is co-expression (As 56.35 %, Cd 64.07 %, Pb 71.5 %, Hg 81.91 %, Ni 64.28 %, Cr 88.51 %). Biological processes, molecular functions, and pathways in which these 25 genes participate are closely related to cytokines and cytokine storm implicated in the development of COVID-19 complications. In other words, our findings confirm that exposure to toxic metals, alone or in combinations, might escalate COVID-19 severity.

Published
2024
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3. Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects

Author

Radovanović, Jelena, primary, Antonijević, Biljana, additional, Baralić, Katarina, additional, Ćurčić, Marijana, additional, Đukić-Ćosić, Danijela, additional, Bulat, Zorica, additional, Javorac, Dragana, additional, Buha Đorđević, Aleksandra, additional, Kotur-Stevuljević, Jelena, additional, Sudar-Milovanović, Emina, additional, Antonijević Miljaković, Evica, additional, Beloica, Miloš, additional, and Mandinić, Zoran, additional

Published
2022
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4. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis

Author

Đukić-Ćosić, Danijela, primary, Baralić, Katarina, additional, Filipović, Teodora, additional, Božić, Dragica, additional, Živančević, Katarina, additional, Miljaković, Evica Antonijević, additional, Đorđević, Aleksandra Buha, additional, Bulat, Zorica, additional, Antonijević, Biljana, additional, and Ćurčić, Marijana, additional

Published
2022
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5. Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Author

Javorac, Dragana, primary, Đorđević, Aleksandra Buha, additional, Anđelković, Milena, additional, Tatović, Simona, additional, Baralić, Katarina, additional, Antonijević, Evica, additional, Kotur-Stevuljević, Jelena, additional, Đukić-Ćosić, Danijela, additional, Antonijević, Biljana, additional, and Bulat, Zorica, additional

Published
2020
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