1. Acute oxalate nephropathy after massive ascorbic acid administration.
- Author
-
Lawton JM, Conway LT, Crosson JT, Smith CL, and Abraham PA
- Subjects
- Acute Kidney Injury metabolism, Acute Kidney Injury pathology, Female, Humans, Injections, Intravenous, Kidney Tubules metabolism, Middle Aged, Acute Kidney Injury chemically induced, Ascorbic Acid poisoning, Calcium Oxalate metabolism, Kidney Tubules pathology
- Abstract
A single 45-g dose of intravenous ascorbic acid, a metabolic precursor of oxalate, was administered to a patient as adjuvant therapy for primary amyloidosis and the nephrotic syndrome. Acute oliguric renal failure occurred. Postmortem histopathologic examination of renal tissue revealed extensive intratubular deposition of crystalline material, which was confirmed as calcium oxalate by a microincineration technique. There were no extrarenal deposits of calcium oxalate. Plasma oxalate and ascorbic acid concentrations were increased. We conclude that therapy with high-dose ascorbic acid is a potential cause of oxalate nephropathy.
- Published
- 1985