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2 results on '"Mehta, Vimal"'

1. Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease.

Author

Mehra, Pratishtha, Mehta, Vimal, Yusuf, Jamal, Sukhija, Rishi, and Aronow, Wilbert S.

Subjects
*ENDOTHELIN receptors, *GENETIC polymorphisms, *MITRAL valve, *PULMONARY hypertension, *PREPROENDOTHELIN, *PULMONARY arterial hypertension, *BONE morphogenetic protein receptors
Abstract

Introduction: Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension.Methods: We studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in 123 subjects with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD) and 123 healthy controls.Results: The mutant homozygous Asn/Asn genotype in Lys198Asn and T/T genotype in His323His polymorphism was more prevalent in the PH-MVD group. Presence of Asn/Asn genotype was significantly associated with an increased risk (odds ratio 3.9).Conclusions: ET-1 and ETA gene polymorphisms are prevalent in the PH-MVD group suggesting that they may predispose to the development of PH. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Pulmonary hypertension in left heart disease.

Author

Mehra, Pratishtha, Mehta, Vimal, Sukhija, Rishi, Sinha, Anjan K., Gupta, Mohit, Girish, M. P., and Aronow, Wilbert S.

Subjects
*PULMONARY hypertension, *HEART diseases, *TRICUSPID valve diseases, *PERSISTENT fetal circulation syndrome
Published
2019
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