1. Altered norepinephrine metabolism in Shapiro's syndrome.
- Author
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Sanfield JA, Linares OA, Cahalan DD, Forrester JM, Halter JB, and Rosen SG
- Subjects
- Aged, Clonidine therapeutic use, Female, Humans, Hypothermia drug therapy, Hypothermia etiology, Middle Aged, Recurrence, Syndrome, Agenesis of Corpus Callosum, Hypothermia metabolism, Norepinephrine metabolism
- Abstract
We studied a 66-year-old woman with spontaneous periodic hypothermia (Shapiro's syndrome) to determine the mechanisms that result in increased plasma norepinephrine (NE) levels. In comparison with age-matched control subjects, compartmental analysis of NE kinetics revealed an increased NE release rate into the extravascular compartment and decreases in NE clearance and volume of distribution of NE in the intravascular compartment. Clonidine therapy was associated with an initial dramatic decrease in the frequency of diaphoretic episodes as well as with a fall in NE release rate and increases in NE clearance and volume of distribution. We conclude that increased NE release and decreased plasma NE clearance result in elevated plasma NE levels in Shapiro's syndrome. Clonidine, which was associated with changes in NE kinetics, may provide effective treatment for this disorder.
- Published
- 1989
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