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There are different decision-making models in medicine for treatment decisions. Shared decision-making model is the most appropriate and widely used model for chronic diseases like Multiple Sclerosis (MS). In this model, the decision making process like treatment options is being discussed step by step between patients and physicians. However, increasing treatment options and medication side effects make the decision-making process more difficult for physicians and reveal the need to share wider knowledge with the patient. In this article we evaluate treatment decision making in patients with MS involving real life experiences.