Search

To the Editor.--A recent issue of CAP Today1 includes the article 'More Than Half of Pathology Trainees in 2012 Were Women.' Many years ago, Lotte Strauss, MD, a pioneering woman [...]

'My friend was ill, I cared for him; he died, I dissected him' --Ascribed to various French physicians One of the many indelible lessons I learned as a resident pathologist [...]

Context.--Immunohistochemistry has become an integral component of the practice of pathology. Newer antibodies allow for increasingly precise diagnoses for tumors that previously could not be easily identified. Recently, immunohistochemical evaluations have begun to allow pathologists to actively assist in determining prognosis and even in selecting therapies. Objective.--To summarize the usefulness of currently available immunostains for the study of liver and gastrointestinal system neoplasms and to make recommendations for panels of immunostains that can be particularly helpful. Data Sources.--Information has been collected from recent literature as well as from personal experience and practice. Conclusions.--Many immunostains are now available for the practicing pathologist that allow for increasing accuracy in diagnosis of liver and gastrointestinal tract neoplasms. Panels of immunostains can be used to differentiate between various tumors and also to identify site of origin in the case of a metastatic neoplasm. Immunostains that allow for prognostic determinations and for guidance in the selection of chemotherapeutic agents can also be used by pathologists to assist in the management of patients with malignant tumors affecting the liver and gastrointestinal tract., This review concentrates on the immunohistochemical phenotypes of the major neoplasms of the liver and gastrointestinal tract and also includes discussion of immunohistochemical and molecular markers that can be useful [...]

* Context.--Autopsy rates for patients dying in hospitals have declined from approximately 50% in the 1950s to 5% or less today. Objective.--To investigate the nature of physician attitudes about autopsy [...]

* Liposarcoma is a rare mesenchymal malignant tumor, which usually originates in the retroperitoneum and the extremities. Seven cases of primary liposarcoma of the liver have been previously reported. We present the eighth case, which occurred in an adult female patient. Primary liposarcoma of the liver, although extremely rare, must be considered in the differential diagnosis of a hepatic mass that develops in a noncirrhotic liver, especially in patients who are potential candidates for orthotopic liver transplantation. Liposarcoma is an absolute contraindication for liver transplantation. (Arch Pathol Lab Med. 2001;125:410-412), A Case Report and Review of the Literature REPORT OF A CASE A 54-year-old African American woman presented 1 year before admission with abdominal distention, pain, nausea, vomiting, and a [...]

Hepatic cirrhosis, characterized by increase in parenchymal changes, has important functional consequences, in contrast to simple fibrosis.[1] --Hans Popper and F. Schaffner Cirrhosis is an end stage of many liver [...]