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Your search keyword '"McKenna RW"' showing total 5 results
Start Over Author "McKenna RW" Journal archives of pathology laboratory medicine
5 results on '"McKenna RW"'

1. In Reply.

Author

Dayton VJ, Linden MA, McKenna RW, Yohe S, Fink J, Park K, and Kubic V

Subjects
Humans, Biopsy, Fine-Needle methods, Bone Marrow pathology, Bone Marrow Cells pathology, Bone Marrow Diseases diagnosis, Specimen Handling methods
Published
2015
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3. An extranodal nasal natural killer/T-cell lymphoma with isochromosome 7q10 as the sole cytogenetic aberration was initially diagnosed via bone marrow biopsy.

Author

Wang HY, Wilson KS, McKenna RW, Xu Y, and Karandikar N

Subjects
Biopsy, Bone Marrow pathology, Diagnosis, Differential, Humans, Killer Cells, Natural pathology, Lymphoma, T-Cell pathology, Male, Middle Aged, Nose Neoplasms pathology, Chromosomes, Human, Pair 7 genetics, Isochromosomes genetics, Lymphoma, T-Cell diagnosis, Lymphoma, T-Cell genetics, Nose Neoplasms diagnosis, Nose Neoplasms genetics
Abstract

We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and "sinusitis" of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+ (dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus- encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of his right nasal vestibule demonstrated an atypical lymphoid infiltrate, which was cytoplasmic CD3+, CD56+, and Epstein-Barr virus-encoded RNA positive, consistent with an extranodal nasal natural killer cell lymphoma. Conventional cytogenetic studies of the bone marrow revealed isochromosome 7q10 [i(7)(q10)] as the sole chromosomal aberration. To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma.

Published
2007
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4. Lymphoproliferative disorder of granular lymphocytes. More questions than answers.

Author

McKenna RW

Subjects
Antigens, Differentiation analysis, Antigens, Differentiation, T-Lymphocyte analysis, CD3 Complex, CD57 Antigens, Cell Division, Gene Expression, Humans, Immunophenotyping, Killer Cells, Natural immunology, Lymphoproliferative Disorders classification, Lymphoproliferative Disorders genetics, Neutropenia pathology, Receptors, Antigen, T-Cell analysis, Receptors, Fc analysis, Receptors, IgG, Antigens, CD analysis, Lymphocytes pathology, Lymphoproliferative Disorders immunology
Published
1992

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