1. Glucocorticoid and Antibiotic Effect on Experimental Gram-Negative Bacteremic Shock
- Author
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Steven Holtzman, Mary Pitcairn, Peter R. Erve, James J. Schuler, and William Schumer
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Dexamethasone ,Dexamethasone Sodium Phosphate ,Escherichia coli ,Animals ,Humans ,Medicine ,Survival rate ,business.industry ,Penicillin G ,Thrombophlebitis ,medicine.disease ,Shock, Septic ,Rats ,Surgery ,Gentamicin Sulfate ,Chloramphenicol ,Bacteremia ,Ampicillin Sodium ,Streptomycin ,Ampicillin ,Gentamicins ,business ,Glucocorticoid ,medicine.drug - Abstract
This study was designed to answer the three following questions: (1) Are glucocorticoids as protective in Gram-negative bacteremic shock as they are in endotoxic shock? (2) Is there any difference in efficacy between a bacteriostatic and a bactericidal antibiotic in bacteremic shock? (3) Does the combination of glucocorticoid with antibiotic potentiate the individual protective effects of both? Bacteremia was induced in male Sprague-Dawley rats by a single intravenous injection of viable Escherichia coli . The results showed that dexamethasone sodium phosphate alone afforded significant protection against Gram-negative bacteremic shock up to eight hours after challenge. The choice of a bactericidal vs a bacteriostatic antibiotic did not influence the survival rates in this study. The survival rate was maximal when dexamethasone was used with both ampicillin sodium and gentamicin sulfate.
- Published
- 1975