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21 results on '"Eisenbrand, Gerhard"'

1. Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment

Author

Leist, Marcel, Buettner, Andrea, Diel, Patrick, Eisenbrand, Gerhard, Epe, Bernd, Först, Petra, Grune, Tilman, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Humpf, Hans-Ulrich, Jäger, Henry, Kulling, Sabine E., Mally, Angela, Marko, Doris, Nöthlings, Ute, Röhrdanz, Elke, Spranger, Joachim, Vieths, Stefan, Wätjen, Wim, and Hengstler, Jan G.

Published
2024
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2. Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food

Author

Eisenbrand, Gerhard, Buettner, Andrea, Diel, Patrick, Epe, Bernd, Först, Petra, Grune, Tillman, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Humpf, Hans-Ulrich, Jäger, Henry, Kulling, Sabine, Lampen, Alfonso, Leist, Marcel, Mally, Angela, Marko, Doris, Nöthlings, Ute, Röhrdanz, Elke, Spranger, Joachim, Steinberg, Pablo, Vieths, Stefan, Wätjen, Wim, and Hengstler, Jan G.

Published
2024
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3. Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food

Author

Eisenbrand, Gerhard, Buettner, Andrea, Diel, Patrick, Epe, Bernd, Först, Petra, Grune, Tilman, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Humpf, Hans-Ulrich, Jäger, Henry, Kulling, Sabine, Lampen, Alfonso, Leist, Marcel, Mally, Angela, Marko, Doris, Nöthlings, Ute, Röhrdanz, Elke, Spranger, Joachim, Steinberg, Pablo, Vieths, Stefan, Wätjen, Wim, and Hengstler, Jan G.

Published
2024
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4. Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis

Author

Eisenbrand, Gerhard, Baum, Matthias, Cartus, Alexander T., Diel, Patrick, Engel, Karl-Heinz, Engeli, Barbara, Epe, Bernd, Grune, Tilman, Guth, Sabine, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Hengstler, Jan G., Henle, Thomas, Humpf, Hans-Ulrich, Jäger, Henry, Joost, Hans-Georg, Kulling, Sabine, Lachenmeier, Dirk W., Lampen, Alfonso, Leist, Marcel, Mally, Angela, Marko, Doris, Nöthlings, Ute, Röhrdanz, Elke, Roth, Angelika, Spranger, Joachim, Stadler, Richard, Vieths, Stefan, Wätjen, Wim, and Steinberg, Pablo

Published
2022
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5. Contribution to the ongoing discussion on fluoride toxicity

Author

Guth, Sabine, Hüser, Stephanie, Roth, Angelika, Degen, Gisela, Diel, Patrick, Edlund, Karolina, Eisenbrand, Gerhard, Engel, Karl-Heinz, Epe, Bernd, Grune, Tilman, Heinz, Volker, Henle, Thomas, Humpf, Hans-Ulrich, Jäger, Henry, Joost, Hans-Georg, Kulling, Sabine E., Lampen, Alfonso, Mally, Angela, Marchan, Rosemarie, Marko, Doris, Mühle, Eva, Nitsche, Michael A., Röhrdanz, Elke, Stadler, Richard, van Thriel, Christoph, Vieths, Stefan, Vogel, Rudi F., Wascher, Edmund, Watzl, Carsten, Nöthlings, Ute, and Hengstler, Jan G.

Published
2021
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8. Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses

Author

Guth, Sabine, Hüser, Stephanie, Roth, Angelika, Degen, Gisela, Diel, Patrick, Edlund, Karolina, Eisenbrand, Gerhard, Engel, Karl-Heinz, Epe, Bernd, Grune, Tilman, Heinz, Volker, Henle, Thomas, Humpf, Hans-Ulrich, Jäger, Henry, Joost, Hans-Georg, Kulling, Sabine E., Lampen, Alfonso, Mally, Angela, Marchan, Rosemarie, Marko, Doris, Mühle, Eva, Nitsche, Michael A., Röhrdanz, Elke, Stadler, Richard, van Thriel, Christoph, Vieths, Stefan, Vogel, Rudi F., Wascher, Edmund, Watzl, Carsten, Nöthlings, Ute, and Hengstler, Jan G.

Published
2020
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12. The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

Author

Rietjens, Ivonne M C M, Arand, Michael, Bolt, Hermann M, Bourdoux, Siméon, Hartwig, Andrea, Hinrichsen, Nils, Kalisch, Christine, Mally, Angela, Pellegrino, Gloria, Ribera, Daniel, Thatcher, Natalie, Eisenbrand, Gerhard, University of Zurich, and Rietjens, Ivonne M C M

Subjects
Life sciences, biology, Health, Toxicology and Mutagenesis, Process-related contaminants, 10050 Institute of Pharmacology and Toxicology, 3005 Toxicology, genotoxins, exposome, endogenous exposure, process-related contaminants, 610 Medicine & health, General Medicine, Genotoxins, Toxicology, Risk Assessment, Exposome, Health, Formaldehyde, ddc:570, 2307 Health, Toxicology and Mutagenesis, Humans, 570 Life sciences, Endogenous exposure, Toxicology and Mutagenesis, Acrolein, Toxicologie, Mutagens, VLAG
Abstract

The “totality” of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only formed in foods by heat processing, but also occur endogenously in the organism as physiological components of energy metabolism, potentially also generated by the human microbiome. To arrive at a comprehensive risk assessment, it is necessary to understand the contribution of in vivo background occurrence as compared to the ingestion from exogenous sources. Hence, this review provides an overview of the knowledge on the contribution of endogenous exposure to the overall exposure to putative genotoxic food contaminants, namely ethanol, acetaldehyde, formaldehyde, acrylamide, acrolein, α,β-unsaturated alkenals, glycation compounds, N-nitroso compounds, ethylene oxide, furans, 2- and 3-MCPD, and glycidyl esters. The evidence discussed herein allows to conclude that endogenous formation of some contaminants appears to contribute substantially to the exposome. This is of critical importance for risk assessment in the cases where endogenous exposure is suspected to outweigh the exogenous one (e.g. formaldehyde and acrolein).

Published
2022

21. Correction to: Mode of action-based risk assessment of genotoxic carcinogens

Author

G. Schriever‐Schwemmer, Hans Jörg Martus, Andrea Hartwig, Michael Arand, Ivonne M.C.M. Rietjens, Alfonso Lampen, Bernhard H. Monien, Simone Schmitz-Spanke, Pablo Steinberg, Bernd Epe, Gerhard Eisenbrand, Sabine Guth, Gunnar Jahnke, University of Zurich, Hartwig, Andrea, and Eisenbrand, Gerhard

Subjects
0301 basic medicine, Health, Toxicology and Mutagenesis, Pharmacology toxicology, 10050 Institute of Pharmacology and Toxicology, 610 Medicine & health, 010501 environmental sciences, Bioinformatics, Toxicology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 2307 Health, Toxicology and Mutagenesis, Life Science, Medicine, Mode of action, Carcinogen, Toxicologie, 0105 earth and related environmental sciences, VLAG, WIMEK, business.industry, 3005 Toxicology, General Medicine, 030104 developmental biology, chemistry, Pyrrolizidine, 570 Life sciences, biology, Risk assessment, business
Abstract

The author would like to thank N. Bakhiya, S. Hessel-Pras, B. Sachse, and B. Dusemund for their support in the chapter about pyrrolizidine alkaloids.

Published
2020

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