1. In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test
- Author
-
Sebastian Kevekordes, R. Edenharder, Gebel T, K. Pav, and Hartmut Dunkelberg
- Subjects
Male ,Health, Toxicology and Mutagenesis ,010501 environmental sciences ,Pharmacology ,Toxicology ,medicine.disease_cause ,01 natural sciences ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Bone Marrow ,In vivo ,medicine ,Animals ,Atrazine ,030304 developmental biology ,0105 earth and related environmental sciences ,0303 health sciences ,Micronucleus Tests ,Herbicides ,Alachlor ,Trifluralin ,General Medicine ,Terbuthylazine ,chemistry ,Toxicity ,Micronucleus test ,Female ,Genotoxicity ,Mutagens - Abstract
The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1,400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.
- Published
- 1997
- Full Text
- View/download PDF