1. Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application
- Author
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K. Norpoth, F. Pott, U. Heinrich, H. Brune, Jürgen Jacob, G. Dettbarn, E. Mohtashamipur, Gernot Grimmer, R. Wenzel-Hartung, and Publica
- Subjects
Male ,Chrysene ,Chromatography, Gas ,Time Factors ,Health, Toxicology and Mutagenesis ,Urinary system ,Metabolite ,excretion(urinary and faecal) ,Administration, Oral ,Ausscheidung ,Pharmacology ,polyzyklischer aromatischer Kohlenwasserstoff ,Toxicology ,Chrysenes ,Excretion ,Feces ,chemistry.chemical_compound ,Route of administration ,Ratte ,Administration, Inhalation ,polycyclic aromatic hydrocarbon ,Intubation, Intratracheal ,Animals ,Rats, Inbred Strains ,General Medicine ,Metabolism ,Phenanthrenes ,Chrysen ,Rats ,Metabolismus ,Biochemistry ,chemistry ,Toxicity ,Gas chromatography ,Injections, Intraperitoneal - Abstract
The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4- position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.
- Published
- 1988