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7. Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific.

Author

Xu, Lei, Zhou, Xinying, Peppelenbosch, Maikel, and Pan, Qiuwei

Subjects
VIRUS diseases, HEPATITIS E virus, VIRAL replication, PROTEASOME inhibitors, UBIQUITINATION, RNA viruses
Abstract

The ubiquitin proteasome system plays important role in virus infection. A previous study showed that the proteasome inhibitor MG132 could potentially affect hepatitis E virus (HEV) replication. In this study, we found that MG132 could inhibit HEV and hepatitis C virus (HCV) replication-related luciferase activity in subgenomic models. Furthermore, treatment with MG132 in a HEV infectious model resulted in a dramatic reduction in the intracellular level of HEV RNA. Surprisingly, MG132 concurrently inhibited the expression of a luciferase gene used as a control as well as a wide range of host genes. Consistently, the total cellular RNA and protein content was concurrently reduced by MG132 treatment, suggesting a nonspecific antiviral effect. [ABSTRACT FROM AUTHOR]

Published
2015
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