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4 results on '"Yang, Xianchao"'

1. Spectrum detection and analysis of the epidemiological characteristics of infectious pathogens in the feline respiratory tract.

Author

Ju, Houbin, Yang, Dequan, Jin, Jizexiao, Wang, Jian, Li, Xin, Yang, Xianchao, Ge, Jie, Zhu, Jiuchao, Shen, Haixiao, Lu, Jun, Wu, Xiujuan, Wang, Xiaoxu, Tang, Yanting, and Chen, Qi

Abstract

Our study was designed to investigate the original spectrum of feline respiratory tract infection and to provide a scientific basis for the clinical diagnosis and treatment of feline respiratory infections and for precise prevention and control measures. A total of 400 cats with upper respiratory tract infections from animal hospitals in 12 provinces in China were examined from November 2022 to October 2023 to investigate the epidemiology of feline calicivirus (FCV), feline herpes virus type 1 (FHV-1), influenza A virus (IAV), Mycoplasma felis, Chlamydia felis, and Bordetella bronchiseptica through loop-mediated isothermal amplification (LAMP) with microfluidic chip detection. The results showed that 396 of the 400 samples tested were positive for at least one of these pathogens, with an overall detection rate of 99.00%. The detection rates were as follows: FCV, 36.00% (144/400); M. felis, 34.00% (136/400); FHV-1, 21.50% (86/400); C. felis, 15.75% (63/400); B. b, 13.00% (52/400); IAV, 4.50% (18/400). There were no statistically significant differences in the detection rates of respiratory pathogens between different sexes, ages, seasons, breeds, or regions (P > 0.05). There were 88 mixed infections, giving a total mixed infection rate of 22.00% (88/400). It is worth noting that the detection rate of FCV at different ages and of FHV-1 in different sexes showed significant differences (P < 0.05). The highest rate of FCV infection was found in animals that were 1 to 2 years old, and the rate of FHV-1 infection in male cats was higher than that in female cats. The results showed that the spectrum of feline respiratory pathogens is complex, with diverse epidemiological characteristics and mixed infections, and some differences among different respiratory pathogens were found with regard to the sex, age, and breed of the cat. Studies should be continued to provide a scientific basis for precise prevention and control of feline respiratory diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Genotypic evolution and antigenicity of H9N2 influenza viruses in Shanghai, China

Author

Fei-Fei Ge, Yafeng Qiu, Liu Peihong, Zhou Jinping, Hou-Bin Ju, Xinyong Qi, Liu Jian, Yang Dequan, Yang Xianchao, Li Xin, and Jian Wang

Subjects
0301 basic medicine, Antigenicity, China, Genotype, Swine, animal diseases, viruses, 030106 microbiology, Reassortment, Hemagglutinin (influenza), Hemagglutinin Glycoproteins, Influenza Virus, medicine.disease_cause, H5N1 genetic structure, Poultry, Evolution, Molecular, 03 medical and health sciences, Orthomyxoviridae Infections, Virology, Influenza, Human, medicine, Influenza A virus, Influenza A Virus, H9N2 Subtype, Animals, Humans, Antigens, Viral, Phylogeny, Poultry Diseases, biology, virus diseases, Antigenic shift, General Medicine, Influenza A virus subtype H5N1, 030104 developmental biology, Influenza Vaccines, Influenza in Birds, biology.protein, Chickens
Abstract

H9N2 influenza viruses have been circulating in China since 1994, but a systematic investigation of H9N2 in Shanghai has not previously been undertaken. Here, using 14 viruses we isolated from poultry and pigs in Shanghai during 2002 and 2006-2014, together with the commercial vaccine A/chicken/Shanghai/F/1998 (Ck/SH/F/98), we analyzed the evolution of H9N2 influenza viruses in Shanghai and showed that all 14 isolates originated from Ck/SH/F/98 antigenically. We evaluated the immune protection efficiency of the vaccine. Our findings demonstrate that H9N2 viruses in Shanghai have undergone extensive reassortment. Various genotypes emerged in 2002, 2006 and 2007, while during 2009-2014 only one genotype was found. Four antigenic groups, A-D, could be identified among the 14 isolates and a variety of antigenically distinct H9N2-virus-derived avian influenza viruses (AIVs) circulated simultaneously in Shanghai during this period. Challenge experiments using vaccinated chickens indicated that the vaccine prevented shedding of antigenic group A and B viruses, but not those of the more recent groups C and D. Genetic analysis showed that compared to the vaccine strain, representative viruses of antigenic groups C and D possess greater numbers of amino acid substitutions in the hemagglutinin (HA) protein than viruses in antigenic groups A and B. Many of these substitutions are located in antigenic sites. Our results indicate that the persistence of H9N2 AIV in China might be due to incomplete vaccine protection and that the avian influenza vaccine should be regularly evaluated and updated to maintain optimal protection.

Published
2015

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