1. Causal effects of neuroticism on postpartum depression: a bidirectional mendelian randomization study.
- Author
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Hu Q, Chen J, Ma J, Li Y, Xu Y, Yue C, and Cong E
- Subjects
- Humans, Female, Risk Factors, Adult, United Kingdom epidemiology, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Causality, Neuroticism, Depression, Postpartum genetics, Depression, Postpartum epidemiology, Mendelian Randomization Analysis, Genome-Wide Association Study
- Abstract
Purpose: Postpartum depression (PPD) brings adverse and serious consequences to both new parents and newborns. Neuroticism affects PPD, which remains controversial for confounding factors and reverse causality in cross-sectional research. Therefore, mendelian randomization (MR) study has been adopted to investigate their causal relationship., Methods: This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results' robustness, heterogeneity, and horizontal pleiotropy. The fixed effect model yielded the results of meta-analysis., Results: In the IVW model, a meta-analysis of the MR study showed that neuroticism increased the risk of PPD (OR, 1.17; 95% CI, 1.11-1.25, pā<ā0.01). Reverse analysis showed that PPD could not genetically predict neuroticism. There was no significant heterogeneity or horizontal pleiotropy bias in this result., Conclusion: Our study suggests neuroticism is the risk factor for PPD from a gene perspective and PPD is not the risk factor for neuroticism. This finding may provide new insights into prevention and intervention strategies for PPD according to early detection of neuroticism., (© 2024. The Author(s).)
- Published
- 2024
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