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Synthesis of biologically promising heterocyclic scaffolds under greener conditions is one of the most promising areas of research today in organic chemistry. Heterogeneous catalysis has received greater attention versus homogeneous catalysis as it is much more beneficial in terms of reusability of the catalysts. Among many others, various heteropoly acids have been used as efficient heterogeneous catalysts for diverse organic transformations. In the present review, we have summarized the literature related to the synthesis of various biologically promising heterocyclic scaffolds utilizing a catalytic amount of one such efficient and reusable heteropoly acid, the Preyssler catalyst. [ABSTRACT FROM AUTHOR]

A simple, efficient and environmentally benign method has been developed for the synthesis of a variety of 2-amino-3-cyano-4-substitued-4H-chromenes in excellent yields. The synthesis was accomplished via one-pot three-component reactions of salicylaldehydes, malononitrile and various nucleophiles in the presence of a catalytic amount of sodium dodecyl sulfate as a surfactant type organocatalyst in water at room temperature. All the nucleophiles afforded the desired products in excellent yields of 82-98%. [ABSTRACT FROM AUTHOR]

A simple, mild, eco-friendly, general and convenient approach has been developed for the synthesis of various trisubstituted methane derivatives via one-pot pseudo three-component reactions between one equivalent of aromatic aldehydes and two equivalents of 6-amino-uracils or dimedone respectively using a catalytic amount of mandelic acid as a low cost, commercially available, efficient organo-catalyst in aqueous ethanol at room temperature. [ABSTRACT FROM AUTHOR]