1. Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
- Author
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Douglas W. Losordo, Roberto Pola, Marta Bosch-Marce, Young Sup Yoon, Cynthia Curry, William E. Munger, Marcy Silver, Kengo Fukushima Kusano, Takayuki Asahara, Rudolf Kirchmair, Karen L. Allendoerfer, and Marianne Kearney
- Subjects
Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Diabetic neuropathy ,Neural Conduction ,Neovascularization, Physiologic ,Vasa Nervorum ,Streptozocin ,Microcirculation ,Diabetes Mellitus, Experimental ,Neovascularization ,Rats, Sprague-Dawley ,Diabetic Neuropathies ,Diabetes mellitus ,Internal medicine ,Vasa nervorum ,medicine ,Laser-Doppler Flowmetry ,Animals ,Humans ,Hedgehog Proteins ,Sonic hedgehog ,Cells, Cultured ,biology ,business.industry ,Fibroblasts ,medicine.disease ,Sciatic Nerve ,Rats ,Perfusion ,Disease Models, Animal ,Endocrinology ,medicine.anatomical_structure ,Regional Blood Flow ,biology.protein ,Trans-Activators ,Arteriogenesis ,medicine.symptom ,Plant Lectins ,Cardiology and Cardiovascular Medicine ,business ,Sensory nerve - Abstract
Objective— The embryonic morphogen sonic hedgehog (SHh) has been shown to induce neovascularization of ischemic tissue but has not been shown to play a role in regulating vascular nerve supply. Accordingly, we investigated the hypothesis that systemic injection of SHh protein could improve nerve blood flow and function in diabetic neuropathy (DN). Methods and Results— Twelve weeks after induction of diabetes with streptozotocin, motor and sensory nerve conduction velocities (MCV and SCV) of the sciatic nerves were significantly reduced in diabetic rats. SHh-treated diabetic rats demonstrated marked improvement of both MCV and SCV ( P P Conclusions— These data indicate that Shh induces arteriogenesis and restores nerve function in DN.
- Published
- 2004