1. Lymphocyte migration into atherosclerotic plaque.
- Author
-
Li J and Ley K
- Subjects
- Animals, Atherosclerosis metabolism, Atherosclerosis pathology, Blood Vessels metabolism, Blood Vessels pathology, Chemokines metabolism, Disease Models, Animal, Humans, L-Selectin metabolism, Lymphocyte Subsets metabolism, Lymphocyte Subsets pathology, Macrophage Migration-Inhibitory Factors metabolism, Mice, Receptors, Chemokine metabolism, Signal Transduction, Atherosclerosis immunology, Blood Vessels immunology, Chemotaxis, Leukocyte, Lymphocyte Subsets immunology, Plaque, Atherosclerotic
- Abstract
Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to atherosclerotic lesions. We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis. Also, we review the role of their receptors CCR5, CCR6, CCR7, CXCR3, CXCR6, and CXCR2/CXCR4 and the role of the L-selectin in mouse models of atherosclerosis., (© 2014 American Heart Association, Inc.)
- Published
- 2015
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