1. Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease
- Author
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Huang, Ngan F, Stern, Brett, Oropeza, Beu P, Zaitseva, Tatiana S, Paukshto, Michael V, and Zoldan, Janet
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Regenerative Medicine ,Cardiovascular ,Transplantation ,Biotechnology ,Bioengineering ,5.2 Cellular and gene therapies ,Adult ,Humans ,Peripheral Arterial Disease ,Biocompatible Materials ,Cell- and Tissue-Based Therapy ,Vascular Surgical Procedures ,Treatment Outcome ,biocompatible materials ,bioprinting ,ischemia ,peripheral arterial disease ,stem cells ,stromal cells ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Peripheral artery disease is an atherosclerotic disease associated with limb ischemia that necessitates limb amputation in severe cases. Cell therapies comprised of adult mononuclear or stromal cells have been clinically tested and show moderate benefits. Bioengineering strategies can be applied to modify cell behavior and function in a controllable fashion. Using mechanically tunable or spatially controllable biomaterials, we highlight examples in which biomaterials can increase the survival and function of the transplanted cells to improve their revascularization efficacy in preclinical models. Biomaterials can be used in conjunction with soluble factors or genetic approaches to further modulate the behavior of transplanted cells and the locally implanted tissue environment in vivo. We critically assess the advances in bioengineering strategies such as 3-dimensional bioprinting and immunomodulatory biomaterials that can be applied to the treatment of peripheral artery disease and then discuss the current challenges and future directions in the implementation of bioengineering strategies.
- Published
- 2024