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1. Prostaglandin E2 and Its Cognate EP Receptors Control Human Adult Articular Cartilage Homeostasis and Are Linked to the Pathophysiology of Osteoarthritis.

Author

Xin Li, Michael Eliman, Muddasani, Prasuna, Wang, James H.-C., Gabriella Cs-Szabo, van Wijnen, Andre J., and Hee-Jeong Im

Subjects
*OSTEOARTHRITIS, *PROSTAGLANDINS, *ARTICULAR cartilage, *PATHOLOGICAL physiology, *POLYMERASE chain reaction, *CARTILAGE cells
Abstract

The article discusses the study which explores the connection between prostaglandin and osteoarthritis (OA) in human adult articular chondrocytes. The study measured cell survival, proliferation and total proteoglyean synthesis in alginate beads by reverse transcription-polymerase chain reaction (PCR) and Western blotting. The study represents effective therapeutic agents for the treatment of OA on human adult articular cartilage in vitro and receptor antagonist.

Published
2009
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