4 results on '"Divi Cornec"'
Search Results
2. A Proinflammatory Cytokine Network Profile in Th1/Type 1 Effector B Cells Delineates a Common Group of Patients in Four Systemic Autoimmune Diseases
- Author
-
Laëtitia Le Pottier, Maria Orietta Borghi, Jacques-Olivier Pers, Lucas Le Lann, Divi Cornec, Quentin Simon, Bénédicte Rouvière, Sophie Hillion, Christophe Jamin, Eléonore Bettachioli, Marta E. Alarcón-Riquelme, Alexis Grasseau, Yves Renaudineau, Rocio Aguilar-Quesada, and Marina Boudigou
- Subjects
Adult ,Male ,Naive T cell ,medicine.medical_treatment ,T cell ,Immunology ,B-Lymphocyte Subsets ,Autoimmune Diseases ,Proinflammatory cytokine ,Arthritis, Rheumatoid ,Interferon-gamma ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Rheumatology ,Humans ,Lupus Erythematosus, Systemic ,Immunology and Allergy ,Medicine ,CXCL10 ,Prospective Studies ,B cell ,Autoantibodies ,Cell Proliferation ,030304 developmental biology ,030203 arthritis & rheumatology ,0303 health sciences ,Scleroderma, Systemic ,Interleukin-6 ,business.industry ,Autoantibody ,Cell Differentiation ,Receptor Cross-Talk ,Middle Aged ,Th1 Cells ,Coculture Techniques ,3. Good health ,Chemokine CXCL10 ,Cross-Sectional Studies ,Sjogren's Syndrome ,Cytokine ,medicine.anatomical_structure ,Cellular Microenvironment ,Cytokines ,Interleukin-2 ,Female ,business ,Biomarkers - Abstract
OBJECTIVE The effector T cell and B cell cytokine networks have been implicated in the pathogenesis of systemic autoimmune diseases, but the association of these cytokine networks with the heterogeneity of clinical manifestations and immune profiles has not been carefully examined. This study was undertaken to examine whether cytokine profiles can delineate distinct groups of patients in 4 systemic autoimmune diseases (systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, and systemic sclerosis). METHODS A total of 179 patients and 48 healthy volunteers were enrolled in the multicenter cross-sectional PRECISE Systemic Autoimmune Diseases (PRECISESADS) study. Multi-low-dimensional omics data (cytokines, autoantibodies, circulating immune cells) were examined. Coculture experiments were performed to test the impact of the cytokine microenvironment on T cell/B cell cross-talk. RESULTS A proinflammatory cytokine profile defined by high levels of CXCL10, interleukin-6 (IL-6), IL-2, and tumor necrosis factor characterized a distinct group of patients in the 4 systemic autoimmune diseases. In each disease, this proinflammatory cluster was associated with a specific circulating immune cell signature, more severe disease, and higher levels of autoantibodies, suggesting an uncontrolled proinflammatory Th1 immune response. We observed in vitro that B cells reinforce Th1 differentiation and naive T cell proliferation, leading to the induction of type 1 effector B cells and IgG production. This process was associated with an increase in CXCL10, IL-6, IL-2, and interferon-γ production. CONCLUSION This composite analysis brings new insights into human B cell functional heterogeneity based on T cell/B cell cross-talk, and proposes a better stratification of patients with systemic autoimmune diseases, suggesting that combined biomarkers would be of great value for the design of personalized treatments.
- Published
- 2021
3. The Epidemiology of Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis in Olmsted County, Minnesota
- Author
-
Ulrich Specks, Divi Cornec, Eric L. Matteson, Cynthia S. Crowson, and Alvise Berti
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Minnesota ,Myeloblastin ,Immunology ,Population ,Microscopic Polyangiitis ,Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ,Churg-Strauss Syndrome ,Article ,Antibodies, Antineutrophil Cytoplasmic ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,cardiovascular diseases ,030212 general & internal medicine ,education ,Survival rate ,Aged ,Peroxidase ,030203 arthritis & rheumatology ,education.field_of_study ,business.industry ,Incidence ,Incidence (epidemiology) ,Mortality rate ,Granulomatosis with Polyangiitis ,Middle Aged ,medicine.disease ,3. Good health ,Survival Rate ,Cohort ,Female ,Microscopic polyangiitis ,Granulomatosis with polyangiitis ,business ,Cohort study - Abstract
Objective To estimate the annual incidence, prevalence, and mortality of antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV) and its subsets, granulomatosis with polyangiitis (Wegener's) (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA), in a US-based adult population. Methods All medical records of patients with a diagnosis of, or suspicion of having, AAV in Olmsted County, Minnesota from January 1, 1996 to December 31, 2015 were reviewed. AAV incidence rates were age- and sex-adjusted to the 2010 US white population. Age- and sex-adjusted prevalence of AAV was calculated on January 1, 2015. Survival rates observed in the study cohort were compared with expected rates in the Minnesota population. Results Of the 58 incident cases of AAV in Olmsted County during the study period, 23 (40%) were cases of GPA, 28 (48%) were cases of MPA, and 7 (12%) were cases of EGPA. Overall, 28 (48%) of the patients with AAV were women and 57 (98%) were white. The mean ± SD age at diagnosis was 61.1 ± 16.5 years. Thirty-four patients (61%) had myeloperoxidase (MPO)–ANCAs, and 17 (30%) were positive for proteinase 3 (PR3)–ANCAs; 5 (9%) were ANCA-negative. The annual incidence of AAV was 3.3 per 100,000 population (95% confidence interval [95% CI] 2.4–4.1). The incidence rates of GPA, MPA, and EGPA were 1.3 (95% CI 0.8–1.8), 1.6 (95% CI 1.0–2.2), and 0.4 (95% CI 0.1–0.6), respectively. The overall prevalence of AAV was 42.1 per 100,000 (95% CI 29.6–54.6). The mortality rate among AAV patients overall, and among patients with EGPA, those with MPA, and those with MPO-ANCAs, was increased in comparison to the Minnesota general population (each P < 0.05), whereas mortality rates among patients with GPA, those with PR3-ANCAs, and ANCA-negative patients did not differ from that in the general population. Conclusion The annual incidence of AAV in Olmsted County, Minnesota over the 20 years of the study was 3.3 per 100,000, with a prevalence of 42.1 per 100,000, which is substantially higher than the rates reported in other areas worldwide. The incidence of GPA was similar to that of MPA. Patients with MPA and those with EGPA, but not patients with GPA, experienced higher rates of mortality than that in the Minnesota general population. MPO-ANCAs were a marker of poor survival in this population of patients with AAV.
- Published
- 2017
4. Brief Report: Ultrasonographic Assessment of Salivary Gland Response to Rituximab in Primary Sjögren's Syndrome
- Author
-
Thierry Marhadour, Valérie Devauchelle-Pensec, Sandrine Jousse-Joulin, Simon Gestin, Emmanuel Nowak, Divi Cornec, Luc Bressollette, Alain Saraux, and Jacques-Olivier Pers
- Subjects
medicine.medical_specialty ,Pathology ,Visual analogue scale ,Immunology ,Placebo ,Gastroenterology ,law.invention ,stomatognathic system ,Rheumatology ,Randomized controlled trial ,law ,Internal medicine ,medicine.artery ,medicine ,Immunology and Allergy ,10. No inequality ,Salivary gland ,business.industry ,3. Good health ,Parotid gland ,medicine.anatomical_structure ,Tears ,Rituximab ,business ,Transverse facial artery ,medicine.drug - Abstract
Objective To evaluate changes in salivary gland echostructure and vascularization after rituximab treatment in patients with primary Sjogren's syndrome (SS). Methods Twenty-eight patients with primary SS included in the multicenter, randomized, double-blind, placebo-controlled Tolerance and Efficacy of Rituximab in Primary Sjogren's Syndrome (TEARS) trial underwent salivary gland ultrasonography before the first placebo or rituximab infusion and then 6 months later. Trial inclusion criteria were scores of ≥50 mm on at least 2 of 4 visual analog scales (VAS) evaluating dryness, pain, fatigue, and global disease; and recent-onset (
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.