1. Minimal clinically important differences of disease activity indices in childhood-onset systemic lupus erythematosus
- Author
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Hermine I. Brunner, Judyann C. Olson, Karen Onel, Sivia K. Lapidus, Marisa S. Klein-Gitelman, Marilynn Punaro, Jun Ying, Edward H. Giannini, and Gloria C. Higgins
- Subjects
Male ,medicine.medical_specialty ,Systemic disease ,Adolescent ,Disease ,Severity of Illness Index ,Article ,Rheumatology ,immune system diseases ,Internal medicine ,Severity of illness ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Prospective Studies ,skin and connective tissue diseases ,Child ,Systemic lupus erythematosus ,Lupus erythematosus ,business.industry ,Minimal clinically important difference ,medicine.disease ,Connective tissue disease ,Antirheumatic Agents ,Physical therapy ,Female ,business - Abstract
Objective To determine the minimal clinically important differences (MCIDs) of validated measures of systemic lupus erythematosus (SLE) disease activity in childhood-onset SLE. Methods Childhood-onset SLE patients (n = 98) were followed every 3 months for up to 7 visits (n = 623 total visits). Disease activity measures (European Consensus Lupus Activity Measure, Systemic Lupus Erythematosus Disease Activity Index, Systemic Lupus Activity Measure, British Isles Lupus Assessment Group, and Responder Index for Lupus Erythematosus [RIFLE]) were completed at the time of each visit. Physician-rated changes in the disease course (clinically relevant improvement, no change, clinically relevant worsening) between visits served as the criterion standard. Results MCIDs defined by mean change scores with improvement and worsening, or those based on the standard error of measurement with stable disease, were both small and did not discriminate well between disease courses (detection rates for improvement or worsening were all
- Published
- 2010