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Your search keyword '"Naoyasu Ueda"' showing total 3 results
Start Over Author "Naoyasu Ueda" Journal arthritis research & therapy
3 results on '"Naoyasu Ueda"'

1. Clinical course of patients with rheumatoid arthritis who continue or discontinue biologic therapy after hospitalization for infection: a retrospective observational study

Author

Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura, Yoshifumi Tada, Hiroaki Niiro, Koichi Akashi, and Takahiko Horiuchi

Subjects
Rheumatoid arthritis, Infection, Biological therapy, Antirheumatic agents, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections. Methods We retrospectively reviewed the clinical records of 230 RA patients with 307 hospitalizations for infections under biologic therapy between September 2008 and May 2014 in 15 institutions for up to 18 months after discharge. The risks of RA flares and subsequent hospitalizations for infections from 61 days to 18 months after discharge were evaluated. Results Survival analyses indicated that patients who continued biologic therapy had a significantly lower risk of RA flares (31.4% vs. 60.6%, P

Published
2022
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2. Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis

Author

Yasutaka Kimoto, Hiroaki Niiro, Masahiro Ayano, Hiroshi Tsukamoto, Takahiko Horiuchi, Yojiro Arinobu, Koichi Akashi, Hiroki Mitoma, Shun ichiro Ohta, Atsushi Tanaka, Naoyasu Ueda, Chikako Kiyohara, Yoshifumi Tada, and Mitsuteru Akahoshi

Subjects
Adult, Male, medicine.medical_specialty, Immunology, Gastroenterology, Polymyositis, Dermatomyositis, Pathogenesis, chemistry.chemical_compound, Progranulins, Rheumatology, Internal medicine, Lactate dehydrogenase, medicine, Immunology and Allergy, Humans, Aged, Aged, 80 and over, business.industry, Chronic interstitial pneumonia, Interstitial lung disease, Middle Aged, medicine.disease, respiratory tract diseases, Cross-Sectional Studies, chemistry, Biomarker (medicine), Intercellular Signaling Peptides and Proteins, Female, business, Lung Diseases, Interstitial, Biomarkers, Research Article
Abstract

Progranulin (PGRN), a pleiotropic growth factor, has emerged as an immunoregulatory molecule. Because the roles of PGRN in dermatomyositis (DM) are still unknown, we investigated whether serum PGRN levels are associated with disease activity and prognosis in DM patients, particularly in those with DM complicated with interstitial lung disease (ILD). The serum levels of PGRN were measured by enzyme-linked immunosorbent assay in patients with DM (n =57; acute/subacute interstitial pneumonia (A/SIP): n =17, chronic interstitial pneumonia (CIP): n =24, without ILD: n =16), polymyositis (PM, n =21; including 6 with ILD) and normal healthy controls (NHCs, n =60). We assessed the correlation between the serum PGRN levels and the activity indexes of ILD or prognosis in DM patients with ILD. Serum PGRN levels were significantly higher in DM patients than in PM patients (P =0.0025) and in NHCs (P

Published
2015

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