1. PNA bearing 5-azidomethyluracil.
- Author
-
Manicardi, Alex, Accetta, Alessandro, Tedeschi, Tullia, Sforza, Stefano, Marchelli, Rosangela, and Corradini, Roberto
- Subjects
SOLID-phase synthesis ,PEPTIDE nucleic acids ,AMINES ,RING formation (Chemistry) ,MONOMERS - Abstract
Fmoc- and Boc-protected modified monomers bearing 5-azidomethyluracil nucleobase were synthesized. Four different solid-phase synthetic strategies were tested in order to evaluate the application of this series of monomers for the solid-phase synthesis of modified PNA. The azide was used as masked amine for the introduction of amide-linked functional groups, allowing the production of a library of compounds starting from a single modified monomer. The azide function was also exploited as reactive group for the modification of PNA in solution via azide-alkyne click cycloaddition. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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