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The antibacterial activity of Ofloxacin (DL 8280, Hoe 280 Tarivid) against Ampicillin-resistant clinical isolates was compared to, Penicillin V, Tetracyclin-HCl, Cefalexin, Cefaclor, Co-trimoxazole and nalidixic acid. Ofloxacin proved to be the most active compound against all species tested.

3-[(2,3-Cyclopenteno-1-pyridinium)-methyl]-7-[2-syn-methoximino-2-(2-aminothiazol-4-yl)-acetamido]-ceph-3-em-4-carboxylate (HR 810) is a new cephalosporin derivative with an extremely broad antimicrobial spectrum. It is active against all bacterial species of clinical relevance, including strains which are frequently resistant towards cephalosporins of the third generation.

A new gamma-globulin preparation obtained by partial enzymatic cleavage of Fc-regions (Gamma-Venin), was effective in i.v. monotherapy in mice, infected with Streptococcus Aronson B, Pneumococcus mucosus and Salmonella typhimurium. These septicemias are characterized by protracted mortality. There was no measurable effect of the gamma-globulin preparation monotherapy in infections with acute course (Staphylococcus aureus 108, E. coli 078). But in all five experimental septicemias the additional administration of the gamma-globulin formulation enhanced the effectivity of cefotaxime or ampicillin. In those animals both antibiotics were effective in lower doses than in animals having obtained only chemotherapy.