Search

Your search keyword '"Y. Tsukinoki"' showing total 1 results
Start Over Author "Y. Tsukinoki" Journal arzneimittel-forschung
1 results on '"Y. Tsukinoki"'

1. Pharmacology of 2-o-chlororbenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a compound with benzodiazepine-like properties

Author

K, Hirose, A, Matsushita, M, Eigyo, H, Jyoyama, A, Fujita, Y, Tsukinoki, T, Shiomi, and K, Matsubara

Subjects
Muscle Relaxants, Central, Glycine, Motor Activity, Rats, Aggression, Lethal Dose 50, Benzophenones, Mice, Anti-Anxiety Agents, Avoidance Learning, Cats, Animals, Humans, Hypnotics and Sedatives, Anticonvulsants, Attention, Drug Interactions
Abstract

2-o-Chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a dipeptido-aminobenzophenone compound, inhibited pentetrazole-induced convulsion and suppressed electroshock-induced fighting behavior in mice, reduced conflict behavior in rats and monkeys, and induced muscle relaxation in cats at lower doses than did diazepam. This pharmacological profile suggests that 45-0088-S can be an active, water-soluble antianxiety agent in man.

Published
1981

Catalog

Books, media, physical & digital resources
See catalog results